Mycoplasma bovis compositions

Abstract

Disclosed herein are Mycoplasma bovis immunogenic compositions useful in raising an immune response in animals against M. bovis. Also disclosed herein are methods for generating a protective response against infections in mammals caused by M. bovis.

1 - 18 . (canceled) 
     
     
         19 . A  Mycoplasma bovis  strain, wherein said strain is deposited with the American Type Culture Collection under accession number PTA-122167, or wherein said strain is a progeny of  M. bovis  strain PTA-122167 wherein said progeny of  M. bovis  strain PTA-122167 is obtained by passaging strain PTA-122167. 
     
     
         20 . An immunogenic composition comprising the  Mycoplasma bovis  strain according to  claim 19 , wherein said strain is a modified live strain. 
     
     
         21 . The immunogenic composition according to  claim 20 , further comprising at least one additional antigen. 
     
     
         22 . The immunogenic composition of  claim 21 , wherein the additional antigen is selected from the group consisting of a virus, a bacterium, a fungus and a parasite. 
     
     
         23 . The immunogenic composition of  claim 20  formulated for administration by a route selected from the group consisting of intramuscular, subcutaneous, intranasal, intratracheal, oral and aerosol. 
     
     
         24 . A method for preventing disease caused by  Mycoplasma bovis  in a bovine animal, comprising administering to the animal the immunogenic composition of  claim 20 . 
     
     
         25 . A method for reducing at least one clinical sign of disease caused by  Mycoplasma bovis  in a bovine animal, comprising administering to the animal the immunogenic composition of  claim 19 . 
     
     
         26 . The method according to  claim 25 , wherein said at least one clinical sign is selected form the group consisting of a lung lesions, pyrexia, cough, lameness, and difficulty breathing. 
     
     
         27 . A method for preventing diseases caused by  Mycoplasma bovis  and another infectious agent of a bovine animal, comprising administering to the animal the immunogenic composition of  claim 22 . 
     
     
         28 . A method for preventing at least one clinical sign of diseases caused by  Mycoplasma bovis  and said additional infectious agent, comprising administering to the animal the immunogenic composition of  claim 22 . 
     
     
         29 . The method according to  claim 28 , wherein said at least one clinical sign is selected form the group consisting of a lung lesions, pyrexia, cough, lameness, and difficulty breathing. 
     
     
         30 . A method of making a  M. bovis  vaccine, the method comprising:
 a) obtaining a culture of  M. bovis  strain, wherein said strain is deposited with the American Type Culture Collection under accession number PTA-122167;   b) further passaging said culture of  M. bovis  at least once;   c) obtaining a clone from said passaged culture; and   d) formulating said clone with a carrier or excipient and, optionally, an adjuvant.