Biophotonic compositions for treating skin and soft tissue wounds having either or both non-resistant and resistant infections

Abstract

The present document describes methods and uses of biophotonic compositions which comprise at least one oxidant and at least one chromophore capable of activating the oxidant, in association with a pharmacologically acceptable carrier for use in the treatment of skin and soft tissue wounds that have either or both non-resistant and resistant infections.

1 . A method of treating a skin or soft tissue wound having a non-resistant or a resistant infection, or both categories of infection, comprising:
 a) applying a biophotonic composition to a patient in need thereof, wherein the biophotonic composition comprises at least one oxidant and at least one chromophore capable of activating the oxidant; and   b) exposing said biophotonic composition to actinic light for a time sufficient for said chromophore to cause activation of said oxidant.   
     
     
         2 . The method according to  claim 1 , wherein the infection is a bacterial infection. 
     
     
         3 . The method according to  claim 2 , wherein the bacterial infection is resistant to antibiotics. 
     
     
         4 .- 8 . (canceled) 
     
     
         9 . The method according to  claim 1 , wherein the infection is an antibiotic resistant infection. 
     
     
         10 . The method according to  claim 1 , wherein the wound is a skin wound. 
     
     
         11 . The method according to  claim 1 , wherein the method promotes the healing of wound. 
     
     
         12 . The method according to  claim 1 , wherein the soft tissue wound comprises an oral disease. 
     
     
         13 . The method according to  claim 1 , wherein said biophotonic composition is exposed to actinic light for a period of less than about 5 minutes. 
     
     
         14 .- 16 . (canceled) 
     
     
         17 . The method according to  claim 1 , wherein the source of actinic light is positioned over an area to be treated. 
     
     
         18 . The method according to  claim 1 , wherein said actinic light is visible light having a peak wavelength from about 400 nm to about 700 nm. 
     
     
         19 . The method according to  claim 1 , wherein the oxidant is chosen from hydrogen peroxide, carbamide peroxide and benzoyl peroxide. 
     
     
         20 . (canceled) 
     
     
         21 . The method according to  claim 1 , wherein the composition further comprises at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin. 
     
     
         22 . The method according to  claim 1 , wherein the composition further comprises at least one gelling agent. 
     
     
         23 . The method according to  claim 22 , wherein the gelling agent is chosen from glucose, modified starch, methyl cellulose, carboxymethyl cellulose, propyl cellulose, hydroxypropyl cellulose, a carbomer, alginic acid, sodium alginate, potassium alginate, ammonium alginate, calcium alginate, agar, carrageenan, locust bean gum, pectin, and gelatin. 
     
     
         24 . The method according to  claim 1 , wherein the chromophore is chosen from a xanthene derivative dye, an azo dye, a biological stain, and a carotenoid. 
     
     
         25 . The method according to  claim 24 , wherein said xanthene derivative dye is chosen from a fluorene dye, a fluorone dye, and a rhodole dye. 
     
     
         26 .- 28 . (canceled) 
     
     
         29 . The method according to  claim 25 , wherein said fluorone dye is chosen from fluorescein and fluorescein derivatives. 
     
     
         30 . The method according to  claim 29 , wherein said fluorescein derivative is chosen from phloxine B, rose bengal, and merbromine. 
     
     
         31 . The method according to  claim 29 , wherein said fluorescein derivative is chosen from Eosin Y, Eosin B and Erythrosine B. 
     
     
         32 . The method according to  claim 31 , wherein said fluorescein derivative is Eosin Y. 
     
     
         33 .- 68 . (canceled)