Kits, compositions and methods for wound treatment and management

Abstract

The inventive subject matter provides compositions and methods for transiently or permanently treating or managing an injury. Contemplated compositions are polymerizable in situ over short time periods, even in the presence of blood, without undue exothermic heat. Contemplated compositions may further comprise an anesthetic, an antiseptic, an adhesion promoter, and/or a vasoconstrictor.

1 . A method of transiently treating an injury wherein at least one of blood and tissue is exposed comprising:
 at least partially filing the injury with a polymerizable composition, the polymerizable composition comprising a silicone mixture, wherein the polymerizable composition polymerizes in the presence of the at least one of the blood and the tissue to form an elastic seal;   wherein the polymerizable composition comprises a first and a second adhesion promoter that synergistically enhance adhesion of the polymerized composition to skin and/or tissue at the injury; and   wherein the seal is removable for subsequent treatment of the injury.   
     
     
         2 . The method of  claim 1 , wherein the silicone mixture comprises: a first silicone elastomer component comprising a first platinum catalyst; and a second silicone elastomer component comprising a silicone crosslinker. 
     
     
         3 . The method of  claim 2 , further comprising applying a base component to the injury prior to at least partially filling the injury with the silicone mixture, wherein the base component comprises at least one of an anesthetic, an antiseptic, an adhesion promoter, a catalyst that accelerates polymerization of the polymerizable composition, and a vasoconstrictor. 
     
     
         4 . The method of  claim 2  wherein the platinum catalyst consists of a rhodium complex in vinyl silicone fluid. 
     
     
         5 . The method of  claim 1 , wherein the polymerizable composition comprises a silicone mixture, and wherein the silicone mixture comprises
 (a) a vinyl end-blocked polydimethylsiloxane as a first silicone elastomer component and a platinum catalyst, and   (b) a vinyl end-blocked polydimethylsiloxane as a second silicone elastomer component and a trimethyl end-blocked methyl-hydrogen siloxane polymer as a silicone crosslinker.   
     
     
         6 . An apparatus for treating a wound comprising a polymerizable composition capable of partially filing an injury; the polymerizable composition further comprising a silicone mixture, wherein the polymerizable composition polymerizes in the presence of the at least one of the blood and the tissue to form an elastic seal;
 wherein the polymerizable composition further comprises a first and a second adhesion promoter that synergistically enhance adhesion of the polymerized composition to skin and/or tissue at the injury.   
     
     
         7 . The apparatus of  claim 6  further comprising a base component that at least partially fills the injury with the silicone mixture, wherein the base component comprises at least one of an anesthetic, an antiseptic, an adhesion promoter, a catalyst that accelerates polymerization of the polymerizable composition, and a vasoconstrictor. 
     
     
         8 . The apparatus of  claim 7  wherein the polymerizable composition comprises a silicone mixture, and wherein the silicone mixture comprises
 (a) a vinyl end-blocked polydimethylsiloxane as a first silicone elastomer component and a platinum catalyst, and 
 (b) a vinyl end-blocked polydimethylsiloxane as a second silicone elastomer component and a trimethyl end-blocked methyl-hydrogen siloxane polymer as a silicone crosslinker. 
 
     
     
         9 . The apparatus of  claim 8  wherein the platinum catalyst consists of a rhodium complex in vinyl silicone fluid.