Mesh Compositions and Methods of Production

Abstract

Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.

What is claimed is: 
     
         1 . A composition for treatment, comprising:
 a synthetic material; and   a collagen-containing tissue matrix encasing the synthetic material;   wherein the collagen-containing tissue matrix is in the form of a freeze dried slurry that prior to freeze drying included between 5% and 35% by volume of the collagen-containing tissue matrix subjected to an acid-swelling process; and   wherein at least a portion of the collagen-containing tissue matrix comprises a smooth layer or skin on a surface of the composition produced during freeze drying of the slurry.   
     
     
         2 . The composition of  claim 1 , wherein the slurry is mechanically moved or rubbed into the synthetic material to force at least some of the slurry into openings in an outer surface of the synthetic material. 
     
     
         3 . The composition of  claim 1 , wherein the smooth layer or skin is on an upper surface and an opposing lower surface of the composition is produced during freeze drying of the slurry. 
     
     
         4 . The composition of  claim 1 , wherein the composition comprises an antimicrobial compound. 
     
     
         5 . The composition of  claim 1 , wherein the composition comprises an anti-inflammatory compound. 
     
     
         6 . The composition of  claim 1 , wherein at least some of the slurry is disposed within openings in an outer surface of the synthetic material. 
     
     
         7 . The composition of  claim 1 , wherein the tensile strength of the synthetic material is greater than a tensile strength of the collagen-containing tissue matrix. 
     
     
         8 . The composition of  claim 1 , wherein the synthetic material is biocompatible. 
     
     
         9 . The composition of  claim 1 , wherein the synthetic material comprises at least one of polypropylene, polytetrafluoroethylene, polyester, terephthalate, polyglycolide, or poly-4-hydroxybutyrate. 
     
     
         10 . The composition of  claim 1 , wherein the synthetic material comprises textured surfaces. 
     
     
         11 . The composition of  claim 1 , wherein the collagen-containing tissue matrix is in the form of the freeze dried slurry that prior to freeze drying included between 5% and 25% by volume of the collagen-containing tissue matrix subjected to the acid-swelling process. 
     
     
         12 . The composition of  claim 1 , wherein the collagen-containing tissue matrix is in the form of the freeze dried slurry that prior to freeze drying included between 5% and 10% by volume of the collagen-containing tissue matrix subjected to the acid-swelling process. 
     
     
         13 . The composition of  claim 1 , wherein the acid-swelling process comprises suspending the collagen-containing tissue matrix in acid and incubating the collagen-containing tissue matrix in the acid until swelling occurs. 
     
     
         14 . The composition of  claim 1 , wherein prior to freeze drying, the collagen-containing tissue matrix was decellularized. 
     
     
         15 . The composition of  claim 1 , wherein prior to freeze drying, the slurry was resuspended in a buffer. 
     
     
         16 . The composition of  claim 1 , wherein the synthetic material comprises at least one of a porous foam, a planar mesh, a monofilament woven material, a multifilament woven material, multi-leveled layers, or multi-directional layers. 
     
     
         17 . The composition of  claim 1 , wherein a tensile strength of the synthetic material is greater than a tensile strength of the collagen-containing tissue matrix. 
     
     
         18 . The composition of  claim 1 , wherein the collagen-containing tissue matrix comprises an acellular tissue matrix. 
     
     
         19 . The composition of  claim 1 , wherein prior to freeze drying, the collagen-containing tissue matrix comprises a group of collagen-containing tissue matrix fragments, at least a portion of the collagen-containing tissue matrix fragments including frayed ends. 
     
     
         20 . A method of treatment, comprising:
 selecting an anatomic site; and   implanting in or on the anatomic site a composition according to  claim 1 .