Metal Tricarbonyl Complexes Comprising Substituted Iminodiactic Acid Ligands and Uses as Radioisotope Tracers

Abstract

This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99m Tc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18(F 18 ) radioisotope, or other radionuclide.

1 . An imaging method comprising injecting into a human a tricarbonyl complex having the formula Re(CO) 3 (N-(2- 18 fluoroethyl)iminodiacetate and imaging the  18 F analog. 
     
     
         2 . The method of  claim 1 , wherein the imaging is renal imaging. 
     
     
         3 . An imaging method comprising injecting into a human a tricarbonyl complex having formula  99m Tc(CO) 3 (N-(2-fluoroethyl)iminodiacetate) and imaging the  99m Tc analog. 
     
     
         4 . The method of  claim 3 , wherein the imaging is renal imaging. 
     
     
         5 . An imaging method comprising injecting into a human a tricarbonyl complex having the formula Re(CO) 3 (N-(2- 18 fluoroethyl)iminodiacetate and the formula  99m Tc(CO) 3 (N-(2-fluoroethyl)iminodiacetate) and imaging the  18 F analog and  99m Tc analog. 
     
     
         6 . The method of  claim 5 , wherein the imaging is renal imaging.