Methods of treating cancer

Abstract

The invention provides methods of treating cancer and methods for selecting treatment approaches for cancer.

What is claimed is: 
     
         1 - 5 . (canceled) 
     
     
         6 . A method for determining whether a subject may benefit from (a) continued treatment with one or more anti-cancer therapies or (b) treatment with an anti-ICOS agonist, the method comprising determining ICOS and/or T-bet levels of peripheral CD4+ T cells of a sample of blood of the subject, wherein detection of increased ICOS and/or T-bet levels relative to a control indicates that the subject may benefit from the continued treatment, optionally in combination with an anti-ICOS antibody agonist, or treatment with an anti-ICOS agonist, when the one or more anti-cancer therapies does not comprise anti-ICOS antibody agonist treatment. 
     
     
         7 . The method of  claim 6 , wherein the method comprises determining ICOS levels of peripheral CD4+ T cells of a sample of blood of the subject, wherein detection of increased ICOS levels relative to a control indicates that the subject may benefit from the continued treatment, optionally in combination with an anti-ICOS antibody agonist, or treatment with an anti-ICOS agonist, when the one or more anti-cancer therapies does not comprise anti-ICOS antibody agonist treatment. 
     
     
         8 . The method of  claim 6 , wherein the method comprises determining T-bet levels of peripheral CD4+ T cells of a sample of blood of the subject, wherein detection of increased T-bet levels relative to a control indicates that the subject may benefit from the continued treatment, optionally in combination with an anti-ICOS antibody agonist, or treatment with an anti-ICOS agonist, when the one or more anti-cancer therapies does not comprise anti-ICOS antibody agonist treatment. 
     
     
         9 . The method of  claim 6 , wherein the method comprises determining ICOS and T-bet levels of peripheral CD4+ T cells of a sample of blood of the subject, wherein detection of increased ICOS or T-bet levels relative to a control indicates that the subject may benefit from the continued treatment, optionally in combination with an anti-ICOS antibody agonist, or treatment with an anti-ICOS agonist, when the one or more anti-cancer therapies does not comprise anti-ICOS antibody agonist treatment. 
     
     
         10 - 76 . (canceled)