Device, system and method for non-invasive monitoring of physiological measurements

Abstract

A device, system and method of non-invasive monitoring of physiological measurements of a subject are disclosed. The method may include: emitting light beams towards skin of the subject, with at least one light source having at least one predetermined polarization, wherein the light beams are emitted at an angle 0°≤α≤90° relative to the normal to the skin surface of the subject; sensing light beams with at least one light sensor positioned at a predetermined distance from the at least one light emitting source; filtering out signals corresponding to detected light beams based on the at least one predetermined polarization of the at least one light source; and determining at least one physiological signal, based on the sensed light beams after filtering. The sensed light beams may pass through at least one of epidermis, dermis, subcutaneous tissue and blood vessel of the subject.

1 . A monitoring device adapted to be removably attachable to a subject's body, the device comprising:
 a measuring unit, comprising:
 at least one light emitting source, configured to emit light beams in at least one predetermined polarization at at least one predetermined first angle between the emitted light beam and the normal to the skin surface of the subject; 
 at least one sensor, located at predetermined distances from the at least one light emitting source, wherein the at least one sensor is configured to detect light beams emitted from the at least one light emitting source at least one predetermined second angle between the reflected light beam and the normal to the skin surface of the subject; and 
 at least one polarizer, coupled to the at least one sensor and configured to filter out light beams correspond to the at least one polarization of the at least one light emitting source; and 
   a controller, coupled to the measuring unit, and configured to receive measurements of the detect light beams and analyze physiological signs of the subject based on the detected light beams to determine at least one physiological signal,   wherein the detected light beams pass through at least one of dermis, subcutaneous tissue and blood vessel of the subject.   
     
     
         2 . The device of  claim 1 , wherein the at least one predetermined first angle is an angle of 0°≤α≤90° between the emitted light beam and the normal to the skin surface of the subject. 
     
     
         3 . The device of  claim 2 , wherein the at least one predetermined first angle is an angle of 40°≤α≤50° between the emitted light beam and the normal to the skin surface of the subject. 
     
     
         4 . The device of  claim 1 , wherein the at least one predetermined second angle is an angle of 0°≤β≤90° between the reflected light beam and the normal to the skin surface of the subject. 
     
     
         5 . The device of  claim 4 , wherein the at least one predetermined second angle is an angle 40°≤β≤50° relative to the normal to the skin surface of the subject. 
     
     
         6 . The device of  claim 1 , wherein the at least one polarizer is configured to filter out signals having the at least one predetermined polarization. 
     
     
         7 . The device of  claim 1 , wherein the monitoring device is wearable. 
     
     
         8 . The device of  claim 1 , comprising:
 a first light source configured to emit light at a first polarization; and   a second light source configured to emit light at a second polarization.   
     
     
         9 . The device of  claim 7 , comprising:
 a first polarizer coupled to the at least one sensor for filtering the first polarization; and   a second polarizer coupled to the at least one sensor for filtering the second polarization.   
     
     
         10 . The device of  claim 1 , wherein the amount of light with polarization corresponding to the polarization of the at least one light emitting source that is filtered out is in the range of 20-50%. 
     
     
         11 . The device of  claim 1 , wherein the at least one sensor is configured to detect light beams for at least one predetermined angle. 
     
     
         12 . The device of  claim 1 , further comprising a modulating unit configured to modulate at least one of the emitted and received light beams to a predetermined frequency. 
     
     
         13 . The device of  claim 12 , wherein the controller is configured to control the modulating unit. 
     
     
         14 . The device of  claim 1 , wherein the at least one light emitting source is configured to emit light beams in at least one predetermined wavelength, and wherein the at least one physiological signal is determined based on the at least one predetermined wavelength. 
     
     
         15 . The device of  claim 1 , further comprising a communication module, configured to allow communication with external computerized devices, wherein the communication module is configured to allow wireless communication. 
     
     
         16 . The device of  claim 1 , further comprising a wire grid as the polarizer. 
     
     
         17 . The device of  claim 1 , wherein the controller is configured to control the polarization of the at least one light emitting source. 
     
     
         18 . A system for non-invasive monitoring of physiological measurements of a subject, the system comprising:
 at least one monitoring device comprising:   a measuring unit, comprising:   at least one light emitting source, configured to emit light beams in at least one predetermined polarization at least one predetermined first angle between the emitted light beam and the normal to the skin surface of the subject;   at least one sensor, located at predetermined distances from the at least one light emitting source, wherein the at least one sensor is configured to detect light beams emitted from the at least one light emitting source at least one predetermined second angle between the reflected light beam and the normal to the skin surface of the subject; and   at least one polarizer, coupled to the at least one sensor and configured to filter out light beams correspond to the at least one polarization of the at least one light emitting source; and   a controller, coupled to the measuring unit, and configured to receive measurements of the detect light beams and analyze physiological signs of the subject based on the detected light beams to determine at least one physiological signal, wherein the detected light beams pass through at least one of dermis, subcutaneous tissue and blood vessel of the subject; and   a processor, in communication with the at least one monitoring device, the processor configured to receive data from the at least one monitoring device and determine at least one physiological signal,   wherein the monitoring device is configured to be removably attachable to the subject's body, and wherein the sensed light beams pass through at least one of dermis, subcutaneous tissue and blood vessel of the subject.