Treatment of bone marrow edema (oedema) with polysulfated polysaccharides

Abstract

A method for the treatment of bone marrow edema in a mammal comprising administering an effective amount of a polysulfated polysaccharide including salts thereof, to a mammal in need of such treatment.

1 - 12 . (canceled) 
     
     
         13 . A method for the treatment of bone marrow edema in the joint of a mammal presumed to be also suffering from osteoarthritis in the joint comprising administering to the mammal from about 1 mg/kg to about 2 mg/kg of the mammal per dose of a sodium salt of pentosan polysulfate, the method including as necessary diagnostically confirming the presence of osteoarthritis in the joint. 
     
     
         14 . The method claim  1  wherein treatment is by administering an injection by the intra-muscular (IM) or subcutaneous (SC) routes, intra-venously (IV), intra-articularly (IA), peri-articularly, topically, via suppositories or orally. 
     
     
         15 . The method according to claim  2  wherein the treatment is by administering an injection intra-muscularly or subcutaneously. 
     
     
         16 . The method, according to claim  3  wherein administration to a human is by dosing in a treatment regimen once daily, twice weekly or thrice weekly. 
     
     
         17 . The method according to claim  4  wherein the total dose of polysulfated polysaccharide administered in the treatment regimen is about 200-2000 mg.