Blended formulations

Abstract

The present invention relates to a formulation comprising blends of formulations (or colloidal dispersions) and its topical application. The formulation comprises at least two different types of colloidal dispersion comprising deformable colloidal particles, wherein the deformable colloidal particles comprise a non-ionic surfactant and/or a phospholipid. The deformable colloidal particles of the invention may comprise an agent of interest (AOI) or may be free of an AOI. The formulation may comprise an AOI that is not associated with the deformable colloidal particles. The present invention also includes kits comprising the formulation of the present invention and the use of the formulation in medicine, skin care and cosmetics.

1 . A formulation comprising a first colloidal dispersion and a second colloidal dispersion, wherein each colloidal dispersion comprises deformable colloidal particles comprising a surfactant and optionally a phospholipid, and wherein one or more of the deformable colloidal particles of the first colloidal dispersion comprise a modified component comprising a first agent of interest (AOI), wherein the modified component is a lipid or surfactant bonded to an AOI, such that the entire AOI is outside the particle membrane, and wherein the first AOI is zinc. 
     
     
         2 . The formulation of  claim 1 , wherein one or more of the deformable colloidal particles of the second colloidal dispersion comprise a second AOI and wherein the first AOI and the second AOI are different. 
     
     
         3 . The formulation of  claim 1 , wherein one or more of the deformable colloidal particles of the first colloidal dispersion and/or one or more of the deformable colloidal particles of the second colloidal dispersion comprise one or more further AOIs and wherein each AOI is different. 
     
     
         4 . The formulation of  claim 1 , wherein the formulation comprises one or more further colloidal dispersions comprising deformable colloidal particles comprising a surfactant and optionally a phospholipid and wherein one or more of the particles of at least two of the dispersions comprise one or more AOIs and wherein the first AOI, second AOI and each further AOI is different. 
     
     
         5 . through  9 . (canceled) 
     
     
         10 . The formulation of  claim 1 , comprising both a modified surfactant component and a modified lipid component, optionally wherein the bond between each AOI and the lipid or surfactant of each modified component is a covalent bond. 
     
     
         11 . (canceled) 
     
     
         12 . The formulation of  claim 2 , wherein the second AOI is selected from the group consisting of an element, an ion, an inorganic salt, a small molecule, an amino acid, a peptide, a protein, a carbohydrate, a lipid, a micronutrient, a macromolecule or a macrocyclic molecule. 
     
     
         13 . The formulation of  claim 2 , wherein the second AOI is selected from the group consisting of zinc, ascorbate, tetrapeptide, tripeptide, salicylic acid, Vitamin D, tocopherol or menthol. 
     
     
         14 . (canceled) 
     
     
         15 . The formulation of  claim 1 , wherein the formulation comprises chlorhexidine, salicylic acid, capsaicin, caffeine or tocopherol, optionally wherein the chlorhexidine, salicylic acid, capsaicin, caffeine or tocopherol is not associated with the deformable colloidal particles. 
     
     
         16 . (canceled) 
     
     
         17 . The formulation of  claim 1 , wherein the formulation comprises at least three colloidal dispersions. 
     
     
         18 . The formulation of  claim 1 , wherein the formulation comprises at least four colloidal dispersions. 
     
     
         19 . The formulation of  claim 1 , wherein the formulation is topically applied. 
     
     
         20 . The formulation of  claim 1 , wherein the formulation is applied weekly, between weekly and daily, daily, twice daily, three times a day or four times a day. 
     
     
         21 . The formulation of  claim 1 , wherein the lipid is phosphatidylcholine. 
     
     
         22 . The formulation of  claim 1 , wherein the surfactant is polysorbate 80. 
     
     
         23 . The formulation of  claim 1 , wherein the formulation further includes one or more buffers, chelators, humectants, lubricants, antioxidants, preservatives, microbicides, antimicrobials, emollients, co-solvents or thickeners. 
     
     
         24 . through  36 . (canceled) 
     
     
         37 . A method of cosmetically improving the appearance of a subject, the method comprising topically applying the formulation of  claim 1  to the skin of a subject. 
     
     
         38 . through  40 . (canceled) 
     
     
         41 . A method of making the formulation of  claim 1 . 
     
     
         42 . A method of treating or preventing a disease in a subject comprising topically applying the formulation of  claim 1  to the subject, wherein the disease is treated, optionally wherein the disease is acne, dry skin, itchy skin, red skin, irritated skin, scaly skin, ageing skin, thinning skin, uneven skin tone, periorbital skin, photo-aged skin or dermatitis. 
     
     
         43 . (canceled) 
     
     
         44 . A method of delivering an AOI to or through the skin of a patient, the method comprising topically applying to the skin of the patient the formulation of  claim 1  in an amount sufficient to penetrate the skin to deliver the AOI. 
     
     
         45 . A kit comprising one or more compartments, wherein at least one compartment contains the formulation of  claim 1 , wherein the kit comprises instructions for administrating the formulation to a subject in need thereof. 
     
     
         46 . (canceled) 
     
     
         47 . (canceled)