Dermal filler

Abstract

Embodiments of the present invention feature a dermal filler comprising a mixture of hyaluronic acid or a pharmaceutically acceptable salt thereof crosslinked with a degree of crosslinking (percent) ranging from 0.5 to 12 in an amount of 0.055 to 2.16% by weight, agarose in an amount between 0.15 to 3.5% agarose by weight and water, sodium chloride, non-gel therapeutic agents, and buffering agents to within a range of ten percent of isotonicity to create a G* value of between 50 and 400.

1 .- 20 . (canceled) 
     
     
         21 . A dermal filler comprising an injectable mixture of:
 hyaluronic acid or a pharmaceutically acceptable salt thereof;   agarose in an amount between 0.15 to 3.5% agarose by weight of the dermal filler;   water, sodium chloride, and buffering agents to within a range of ten percent of isotonicity to create a G* value of between 50 and 400.   
     
     
         22 . The dermal filler of  claim 21 , wherein the G* value is greater than about 200. 
     
     
         23 . The dermal filler of  claim 21 , having a gel structure that is made of approximately 10 to 70% by volume of the agarose and 90 to 30% percent by volume of the hyaluronic acid or pharmaceutically acceptable salt thereof. 
     
     
         24 . A system of dermal fillers comprising at least one first dermal filler and one second dermal filler, said first dermal filler and said second dermal filler each being independently selected from the dermal filler according to  claim 21 , wherein said first filler has a first G* and said second dermal filler has a second G* value which is different from said first G* value. 
     
     
         25 . A method of effecting an aesthetic modification, the method comprising the steps of:
 providing the dermal filler according to  claim 21 ; and   placing said dermal filler to fill a void, expand a skin surface, add volume and/or diminish the appearance of wrinkles and creases.