Cryogenic, kinetically active formulations and systems for their dispensing

Abstract

A cryogenic, kinetically active formulation in a pressurized package; the package; and a method of making the formulation and the package.

1 . A pressurized package comprising a formulation, the formulation comprises one or more active agents, which one or more active agents in the formulation is mixed at high speed under controlled pressure and temperature with one or more liquid refrigerants prior to being filled under pressure into said package;
 wherein said one or more liquid refrigerants are added in sufficient amounts to be dispersed in the formulation;   wherein said pressurized package is under sufficient pressure suitable to maintain the one or more liquid refrigerants dispersed in the formulation; and   wherein said pressurized package is under sufficient pressure to expel said formulation as a cryogenic, kinetically active formulation upon application of external force on said formulation in said package; wherein said one or more liquid refrigerants are non-flammable liquid refrigerants, wherein the one or more non-flammable liquid refrigerants comprise 1,1,1,3,3-Pentafluoropropane (Honeywell HFC-245FA), and either or both trans-1,3,3,3-Tetrafluoroprop-1-ene (Honeywell Solstice 1234ZE), 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD).   
     
     
         2 - 9 . (canceled) 
     
     
         10 . The package of  claim 1 , wherein said formulation is for topical application. 
     
     
         11 . The package of  claim 1 , wherein
 said package is a bag on valve (BOV) pressurized assembly, comprising a two-way fill/dispensing valve, an attached internal high barrier bag affixed to said valve, and rigid container adapted to holding positive pressure affixed to the valve.   
     
     
         12 . The package of  claim 11 , wherein said container is glass, barrier resin, metal/alloy, or another material capable of holding positive pressure. 
     
     
         13 . The package of  claim 11 , wherein the BOV pressurized assembly dispenses the formulation in a metered dispensing system. 
     
     
         14 . The package of  claim 1 , wherein the package does not need to be shaken vigorously or at all to expel said formulation as a cryogenic, kinetically active formulation upon application of external force on said formulation in said package. 
     
     
         15 - 16 . (canceled) 
     
     
         17 . A cryogenic, kinetically active formulation expelled from a pressurized package, the formulation comprises one or more active agents, which one or more active agents in the formulation is mixed at high speed under controlled temperature and pressure with one or more liquid refrigerants prior to being filled under pressure into said package and expelled from said package;
 wherein said one or more liquid refrigerants are added in sufficient amounts to be dispersed in the formulation;   wherein said pressurized package is under sufficient pressure suitable to maintain the one or more liquid refrigerants dispersed in the formulation; and wherein said pressurized package is under sufficient pressure to expel said formulation as a foamlike, cryogenic, kinetically active formulation upon application of external force on said formulation in said package; wherein said one or more liquid refrigerants are non-flammable liquid refrigerants, wherein the one or more non-flammable liquid refrigerants comprise 1,1,1,3,3-Pentafluoropropane (Honeywell HFC-245FA), and either or both trans-1,3,3,3-Tetrafluoroprop-1-ene (Honeywell Solstice 1234ZE), 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD).   
     
     
         18 - 21 . (canceled) 
     
     
         22 . The formulation of  claim 17 , wherein the one or more non-flammable liquid refrigerants are about 40% of the formulation;
 wherein the one or more non-flammable liquid refrigerants are trans-1,3,3,3-Tetrafluoroprop-1-ene (Honeywell Solstice 1234ZE) and 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD); and wherein the proportion of trans-1,3,3,3-Tetrafluoroprop-1-ene (Honeywell Solstice 1234ZE) to 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD) is 3 to 1.   
     
     
         23 . The formulation of  claim 22 , wherein the percentage of 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD) is about 0.1% to about 100% of the total amount of non-flammable liquid refrigerants in the formulation. 
     
     
         24 . The formulation of  claim 23 , wherein the percentage of 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD) is about 0.5% to about 100% of the total amount of non-flammable liquid refrigerants in the formulation. 
     
     
         25 . The formulation of  claim 24 , wherein the percentage of 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD) is about 0.5% to about 94% of the total amount of non-flammable liquid refrigerants in the formulation. 
     
     
         26 . The formulation of  claim 17 , wherein at least some of the refrigerants are liquid and the liquid refrigerants are solubilized in the formulation and small micro-pockets of liquid propellants are captured in the formulation. 
     
     
         27 . The formulation of  claim 17 , wherein said formulation is for topical application. 
     
     
         28 - 31 . (canceled) 
     
     
         32 . The formulation of  claim 17 , wherein the one or more active agents are pain reduction products or skin tighteners. 
     
     
         33 . A method of preparing a cryogenic, kinetically active formulation, comprising:
 controlled mixing at high speed in a high shear, continuous-flow, high-pressure whipping head of sufficient amounts of one or more non-flammable liquid refrigerants with a composition comprising one or more active agents under pressure, wherein pressure and temperature are carefully controlled during mixing, resulting in a formulation having the liquid refrigerants saturated into the formulation;   filling said formulation under pressure into a package;   wherein said one or more liquid refrigerants are added in sufficient amounts to be dispersed in the formulation and expelling the formulation from the package as a cryogenic, kinetically active formulation;   wherein said pressurized package is under sufficient pressure suitable to maintain the one or more liquid refrigerants dispersed in the formulation;   and wherein said pressurized package is under sufficient pressure to expel said formulation as a cryogenic, kinetically active formulation upon application of external force on said formulation in said package; wherein said one or more non-flammable liquid refrigerants comprise Honeywell Solstice propellant 1234ze and/or Honeywell Solstice performance fluid 1233zd and/or HFC-245FA.   
     
     
         34 - 48 . (canceled) 
     
     
         49 . The method of  claim 33 , wherein the one or more non-flammable liquid refrigerants are 40% of the formulation.