Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof

Abstract

The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.

1 - 45 . (canceled) 
     
     
         46 . A composition of perfluoropentane nanoemulsion comprising:
 perfluoropentane; and   one or more surfactants selected from perfluoro-n-hexyl-oligoethyleneoxy-alcohols,   
       wherein the nanoemulsion is characterized by:
 perfluoropentane accounting for a weight percent in the nanoemulsion from about 1% to about 10%, 
 the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounting for a weight percent in the nanoemulsion from about 0.10% to about 7.5%, 
 a particle distribution wherein 99% of the particles are measured to have particle diameters of less than or equal to 400 nm, and 
 the perfluoro-n-hexyl-oligoethyleneoxy-alcohol is selected from the group consisting of: 
 
       
         
           
           
               
               
           
         
       
     
     
         47 . The composition of  claim 46 , wherein the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounts for a weight percent in the nanoemulsion from about 0.10% to about 1.5%. 
     
     
         48 . A composition of a fluorocarbon nanoemulsion comprising:
 perfluoropentane; and   a perfluoro-n-hexyl-oligoethyleneoxy-alcohol as a surfactant,   
       wherein the nanoemulsion is characterized by:
 perfluoropentane accounting for a weight percent in the nanoemulsion from about 1% to about 10%, 
 the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounting for a weight percent in the nanoemulsion from about 0.10% to about 7.5%, 
 a particle distribution wherein 99% of the particles are measured to have particle diameters of less than or equal to 400 nm, and 
 the perfluoro-n-hexyl-oligoethyleneoxy-alcohol is selected from the group consisting of: 
 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         49 . The composition of  claim 48 , wherein the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounts for a weight percent in the nanoemulsion from about 0.10% to about 1.5%.