Compositions and methods affecting exercise performance

Abstract

Described herein are compositions comprising activators of TRP and ASIC channels that may be useful to improve or preserve exercise performance and exercise recovery.

1 . A method of improving or preserving physical performance during exercise in a subject, wherein the method comprises orally administering to the subject a composition comprising capsicum, ginger, cinnamon and an excipient, wherein improving or preserving physical performance during exercise in a subject is a decrease in the fatigue of the subject. 
     
     
         2 .- 20 . (Canceled) 
     
     
         21 . The method of  claim 1 , wherein:
 (a) the amount of capsicum in the composition is in the range of 0.001% (w/w) to 1% (w/w); or   (b) the amount of ginger in the composition is in the range of 0.001% (w/w) to 1% (w/w); or   (c) the amount of cinnamon in the composition is in the range of 0.001% (w/w) to 1% (w/w).   
     
     
         22 . The method of  claim 1 , wherein the excipient is selected from the group consisting of an antioxidant, a binder, a coloring agent, a disintegrant, an emulsifier, a flavoring agent, a lubricant, a pH-adjusting agent, a preservative, a surfactant, a sweetener, and viscosity modifier. 
     
     
         23 . The method of  claim 1 , wherein the method further comprises administering to the subject an amount of composition in the range of 10 mL to 1000 mL. 
     
     
         24 . The method of  claim 1 , wherein the composition is administered to the subject prior to commencement of exercise. 
     
     
         25 . The method of  claim 1 , wherein the composition is a beverage. 
     
     
         26 . The method of  claim 1 , wherein improving or preserving physical performance during exercise in a subject is a decrease in the fatigue of the subject as measured by the Fatigue Index.