Compounds and compositions for the treatment of muscular disorders and bone disorders

Abstract

The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, and for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject. Further aspects relate to the same or similar applications for bone and bone diseases.

1 . A method to induce increased cellular or muscular or bodily production of follistatin and follistatin-like proteins in order to reverse or ameliorate injury to, or weakness of, or loss of, bone, or to prevent fractures, in a subject in need thereof, comprising administering to a subject a therapeutically effective dose of (+)-epicatechin and/or (−)-epicatechin or an epicatechin derivative of either (+)-epicatechin or (−)-epicatechin 
     
     
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