Sterol derivatives and preparation method and uses thereof

Abstract

The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ═O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ═O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.

What is claimed is: 
     
         1 . An extract from dry powder of content of Xuezhikang capsules or from  Monascus -fermented rice, comprising a compound of Formula (II): 
       
         
           
           
               
               
           
         
       
     
     
         2 . The extract of  claim 1 , wherein the compound of Formula II is present in the dry powder of content of Xuezhikang capsules or  Monascus -fermented rice at an amount of 0.0001-5% (w/w). 
     
     
         3 . The extract of  claim 1 , wherein the compound of Formula II is present in the dry powder of content of Xuezhikang capsules or  Monascus -fermented rice at an amount of 0.001-2% (w/w). 
     
     
         4 . The extract of  claim 1 , wherein the compound of Formula II is present in the dry powder of content of Xuezhikang capsules or  Monascus -fermented rice at an amount 0.001-1% (w/w).