Exosomes from clonal progenitor cells

Abstract

The invention provides methods, compositions, uses and kits relating to exosomes isolated from progenitor cells.

1 .- 10 . (canceled) 
     
     
         11 . A method of inducing or enhancing a cell's ability to form vascular tube like structures comprising contacting a cell capable of making vascular tube like structures with an exosome isolated from a progenitor cell thereby inducing or enhancing a cell's ability to form vascular tube like structures. 
     
     
         12 . The method of  claim 11 , wherein the cell capable of making vascular tube like structures is an endothelial cell. 
     
     
         13 . The method of  claim 12 , wherein the endothelial cell is a HUVEC. 
     
     
         14 . A method of providing or sustaining vasculature in a natural or an artificial organ for transplantation, the method comprising contacting the natural or artificial organ with an exosome isolated from a clonal progenitor cell. 
     
     
         15 . The method of  claim 14 , wherein the clonal progenitor cell is positive for the expression of PCDHB2. 
     
     
         16 . The method of  claim 14 , wherein the exosome comprises CD63. 
     
     
         17 . A method of treating a degenerative disease associated with vascular aging in a subject in need of treatment, the method comprising administering to the subject an exosome isolated from a clonal progenitor cell. 
     
     
         18 . The method of  claim 17 , wherein the degenerative disease associated with vascular aging is sarcopenia, dementia, chronic wounds, osteoporosis, cardiovascular disease, heart failure, infarction, chronic wounds, ulcer, clogged vessels or arteries, damaged vessels, stenotic vessels, arteriosclerosis, angina, peripheral vascular disease, Alzheimer's disease, ischemia, diabetes, cancer, a disease associated with cell replacement transplant or therapy, a disease associated with tissue and cell regenerative therapy, Parkinson's disease, stroke, or any combination thereof. 
     
     
         19 . The method of  claim 17 , wherein the clonal progenitor cell line is positive for the expression of PCDHB2. 
     
     
         20 . The method of  claim 17 , wherein the exosome comprises CD63.