Dual lever dermal patch system

Abstract

A system includes an applicator and a dermal patch coupled to the applicator. The applicator includes a needle configured to puncture a subject's skin to draw a physiological sample, a first actuating lever configured to move form an undeployed position to a deployed position, and a second actuating lever configured to move form an undeployed position to a deployed position. The dermal patch includes a fluid reservoir configured to store a processing fluid, a sample collection chamber configured to receive the processing fluid and the physiological sample, wherein the applicator is configured to cause the needle to puncture the subject's skin to draw the physiological sample when the first actuating lever is moved from the undeployed lever position to the deployed lever position and cause the processing fluid to release from the fluid reservoir when the second actuating lever is moved from the undeployed position to the deployed position.

What is claimed is: 
     
         1 . A dermal patch system, comprising:
 an applicator including:
 a needle configured to puncture a subject's skin to draw a physiological sample; 
 a latch configured to maintain a locked position so as to inhibit activation of the needle when the needle is in an undeployed position; 
   a dermal patch configured for coupling to said applicator such that upon coupling of the applicator to the dermal patch such that the latch can be released to actuate the needle to puncture the skin for drawing a physiological sample.   
     
     
         2 . The dermal patch system of  claim 1 , wherein said dermal patch includes a sample collection chamber for receiving said drawn physiological sample. 
     
     
         3 . The dermal patch system of  claim 1 , wherein the dermal patch is configured for removably coupled to the applicator. 
     
     
         4 . The dermal patch system of  claim 1 , wherein the physiological sample includes blood. 
     
     
         5 . The dermal patch system of  claim 1 , further comprising an adhesive layer coupled to the dermal patch, wherein the adhesive layer is configured to attach to skin of the subject. 
     
     
         6 . The dermal patch system of  claim 1 , wherein the dermal patch further includes a sensor for detecting at least one target analyte in the physiological sample. 
     
     
         7 . The dermal patch system of  claim 6 , wherein the sensor is configured to detect the target analyte when the target analyte is present in the drawn physiological sample at a concentration level greater than a threshold amount. 
     
     
         8 . The dermal patch system of  claim 1 , wherein said target analyte includes a biomarker. 
     
     
         9 . The dermal patch system of  claim 8 , wherein said biomarker is any of troponin, brain natriuretic peptide (BnP), myelin basic protein (MBP), ubiquitin carboxyl-terminal hydrolase isoenzyme L1 (UCHL-1), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), S100-B, Cardiac troponin I protein (cTn1), Cardiac troponin T protein (cTnT), C-reactive protein (CRP), B-type natriuretic peptide (BNP), Myeloperoxidase, Creatine kinase MB, Myoglobin, Hemoglobin, or HbA1C. 
     
     
         10 . The dermal patch system of  claim 6 , wherein said sensor includes any of an immunoassay sensor, an isothermal amplification detection system, a graphene-based sensor, an electrochemical sensor, and a chemical sensor. 
     
     
         11 . The dermal patch system of  claim 1 , wherein said dermal patch includes a fluid reservoir storing a processing fluid. 
     
     
         12 . The dermal patch system of  claim 11 , wherein the processing fluid includes a reagent for isothermal amplification of the target analyte.