Polyketide compound and derivatives thereof for use in the prevention and treatment of a neurological disorder

Abstract

A compound, in particular a polyketide compound and derivatives thereof, for use in prevention and/or treatment of a neurological disorder in an individual. The compound can promote lactate secretion. A composition can contain the compound, and a food or food extract can be enriched with said compound or composition.

The invention is claimed as follows: 
     
         1 . A compound of general structural formula (Ia) 
       
         
           
           
               
               
           
         
         wherein R1 to R9 are individually selected from H and CH3; and 
         R10 to R17 are individually selected from H, C═O, and OH; 
         or a salt thereof for use in the promotion of lactate secretion in an individual. 
       
     
     
         2 . The compound according to  claim 1 , wherein the compound is a macrolide. 
     
     
         3 . The compound according to  claim 1 , wherein the compound is further modified by one or more of:
 a. Reduction of a carbonyl to a hydroxyl group   b. Dehydration   c. Double bond reduction.   
     
     
         4 . The compound according to  claim 1 , wherein the compound is lactonised between the carboxylic acid group at position 19 and the alcoholic group at position 3, creating an 18 atom ring to form compound A: 
       
         
           
           
               
               
           
         
       
     
     
         5 . A composition comprising the compound according to  claim 1 , wherein the composition is a pharmaceutical or nutraceutical composition. 
     
     
         6 . A method for prevention or treatment of a neurological disorder and/or improvement of memory function, the method comprising administering a compound of general structural formula (Ia) 
       
         
           
           
               
               
           
         
         wherein R1 to R9 are individually selected from H and CH3; and 
         R10 to R17 are individually selected from H, C═O, and OH; 
         or a salt thereof for use in the promotion of lactate secretion in an individual to an individual in need of same.