Device for in-vitro modelling in-vivo tissues of organs

Abstract

A device for in-vitro modelling in-vivo tissues of organs that includes a device for in-vitro modelling in-vivo tissues of organs, the device including an open access chamber, a perfusion channel, and a culturing membrane dividing the access chamber from the perfusion channel, wherein the culturing membrane is porous and flexible and/or elastic.

1 . A device for in-vitro modelling in-vivo tissues of organs, the device comprising:
 an open access chamber;   a perfusion channel; and   a culturing membrane dividing the access chamber from the perfusion channel, wherein the culturing membrane is porous and flexible and/or elastic.   
     
     
         2 . The device of  claim 1 , comprising a first body portion with the access chamber. 
     
     
         3 . The device of  claim 1 , wherein the first body portion is plate-shaped. 
     
     
         4 . The device of  claim 1 , comprising a second body portion with the perfusion channel. 
     
     
         5 . The device of  claim 4 , wherein the second body portion is plate-shaped. 
     
     
         6 . The device of  claim 4 , wherein the second body portion comprises a culturing chamber. 
     
     
         7 . The device of  claim 4 , comprising a first body portion with the access chamber, wherein the first body portion and the second body portion are one physical unit. 
     
     
         8 . The device of  claim 1 , wherein the perfusion channel has an inlet and an outlet. 
     
     
         9 . The device of  claim 1 , comprising a third body portion configured to cover the perfusion channel. 
     
     
         10 . The device of  claim 9 , wherein the third body portion is plate-shaped. 
     
     
         11 . The device of  claim 9 , wherein the third body portion is a second physical unit. 
     
     
         12 . The device of  claim 11 , comprising a first body portion with the access chamber, wherein the second physical unit is configured to be assembled to the first body portion. 
     
     
         13 . The device of  claim 12 , wherein the second physical unit and the first body portion are configured to be assembled by a holder by mechanic, electric or magnetic forces, or by a combination thereof. 
     
     
         14 . The device of  claim 1 , wherein the device is configured to be implanted. 
     
     
         15 . The device of  claim 14 , wherein the device is coated with a hydrogel. 
     
     
         16 . The device of  claim 1 , wherein the access chamber is open in a vertical upward direction such that the culturing membrane is accessible top-down through the access chamber. 
     
     
         17 . The device of  claim 1 , comprising a fourth body portion configured to cover the access chamber. 
     
     
         18 . The device of  claim 1 , wherein the culturing membrane is made of a silicone rubber. 
     
     
         19 . The device of  claim 1 , wherein the culturing membrane has a thickness that is in a range between about 0.01 μm and about 20 μm. 
     
     
         20 . The device of  claim 1 , wherein diameters of pores are in a range between about 0.4 μm and about 12 μm. 
     
     
         21 . The device of  claim 1 , wherein diameters of pores are about 3 μm.