Antifouling Polymeric Coating Compositions

Abstract

Provided herein are compositions comprising: (a) a polymeric catechol binder, such as: polymeric dopamine, polymeric norepinephrine, polymeric epinephrine; polymeric pyrogallol, polymeric tannic acid, polymeric hydroxyhydroquinone, polymeric catechin, polymeric epigallocatechin etc.; and (b) a hydrophilic polymer, methods for using the compositions to coat a substrate, and methods for making the compositions. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

1 - 45  (canceled) 
     
     
         46 . A composition, the composition comprising:
 (a) a polymeric binder, wherein the polymeric binder is selected from one or more of: polymeric norepinephrine (PNE); polymeric pyrogallol (PPG); and polymeric tannic acid (PTA); and   (b) a hydrophilic polymer, wherein the hydrophilic polymer is selected from one or more of: poly(acrylamide) (PAM); poly(N,N-dimethyl acrylamide) (PDMA); poly(N-hydroxymethyl acrylamide) (PHMA); poly(N-hydroxyethyl acrylamide) (PHA); poly {N-[tris(hydroxymethyl) methyl]acrylamide} (PTHMAM); poly(methacrylamide) (PMA); poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA); poly(N-(3-(methacryloylamino)propyl)-N,N-dimethyl-N-(3-sulfopropyl) ammonium hydroxide) (PMPDSAH); and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC);   wherein the hydrophilic polymer is a high molecular weight hydrophilic polymer having a molecular weight ≥100,000 daltons and wherein the composition is suitable for application to a substrate and forms a stable mixture when in solution prior to contact with a substrate.   
     
     
         47 . The composition of  claim 46 , wherein the composition further comprises:
 (a) a buffer;   (b) an aqueous solution;   (c) a water soluble organic solvent; or   (d) water.   
     
     
         48 . The composition of  claim 47 , wherein: (a) the aqueous solution lacks a salt; (b) the buffer has a pH of between 7 and 12; or (c) the buffer comprises a salt. 
     
     
         49 . The composition of  claim 46 , wherein the ratio of a polymeric binder to hydrophilic polymer in mg/ml_is: (a) between 100:1 and 1:100; (b) between 1:1 and 1:30; or (c) between 1:5 and 1:15. 
     
     
         50 . The composition of  claim 46 , wherein the hydrophilic polymer has a number average molecular weight (M n ) of:
 (a) at least 100 kDa;   (b) at least 200 kDa.; or   (c) at least 300 kDa.   
     
     
         51 . The composition of  claim 46 , wherein the polymeric binder is:
 (a) selected from one or more of: PNE; and PTA;   (b) PNE;   (c) PTA; or   (d) PPG.   
     
     
         52 . The composition of  claim 46 , wherein the hydrophilic polymer is:
 (a) selected from one or more of: poly(acrylamide) (PAM); poly(N,N-dimethyl acrylamide) (PDMA); poly(N-hydroxymethyl acrylamide) (PHMA); poly(N-hydroxyethyl acrylamide) (PHEA); poly {N-[tris(hydroxymethyl) methyl]acrylamide} (PTHMAM); poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA); poly(N-(3-(methacryloylamino)propyI)-N,N-dimethyl-N-(3-sulfopropyl) ammonium hydroxide) (PMPDSAH); polv(carboxybetaine methacrylate) (PCBMA); and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC),   (b) selected from one or more of: PAM; PDMA; PHMA; PHEA; and PHPMA; or   (c) PDMA.   
     
     
         53 . A coated substrate, the coated substrate comprising:
 (a) a substrate;   (b) a polymeric binder, wherein the polymeric binder is selected from one or more of: polymeric norepinephrine (PNE); polymeric pyrogallol (PPG); and polymeric tannic acid (PTA); and   (c) a hydrophilic polymer, wherein the hydrophilic polymer is selected from one or more of: PAM, PDMA, PHMA, PHEA ;  PTHMAM, PMA, PHPMA, PMPDSAH, PMPC, and Dextran;   
       wherein the hydrophilic polymer is a high molecular weight hydrophilic polymer having a molecular weight ≥100,000 daltons. 
     
     
         54 . The coated substrate of  claim 53 , wherein the substrate is a plastic, a metal, a ceramic, a carbon based material, a metal oxide, a hydrogel, a biological tissue, a wood or a cement. 
     
     
         55 . The coated substrate of  claim 53 , wherein the substrate is:
 (a) selected from poly(propylene) (PP); poly(urethane) (PU); poly(ethylene) (PE); unplasticized polyvinyl chloride (uPVC); plasticized polyvinyl chloride (pPVC); poly(imide) (PI); ethylene vinyl acetate (EVA); poly(tetrafluoroethylene) (PTFE); titanium dioxide (TiO 2 ), and silicon dioxide (SiO 2 );   (b) selected from PP, PU, PE, uPVC, pPVC, PI, EVA, and PTFE; or   (c) is TiO 2  or SiO 2 .   
     
     
         56 . The coated substrate of  claim 53 , wherein the substrate forms part of an apparatus, 
     
     
         57 . The coated substrate of  claim 56 , wherein the apparatus is selected from: a urinary device; a dental fixture; an artificial joint; a vascular device; a storage device; a microfluidic device; a filtration membrane; a feed tube; or a diagnostic device. 
     
     
         58 . The coated substrate of  claim 57 . wherein:
 (a) the vascular device is selected from a catheter, a lead, and a stent;   (b) the urinary device is selected from a urine storage device, catheter, and a stent; or   (c) the filtration membrane is selected from a blood filtration membrane, a water purification membrane, and an air purification membrane.   
     
     
         59 . A method of coating a substrate, wherein the substrate is immersed in a solution comprising the composition of  claim 46  or the substrate is sprayed with a solution comprising the composition of  claim 46 . 
     
     
         60 . The method of  claim 59 , wherein the method further comprises one or more of the following:
 (a) drying the substrate;   (b) applying a further coat of the solution following the drying of the substrate;   (c) a second drying of the substrate;   (d) one or more repetitions of the applying a further coat of the solution followed by one or more subsequent drying steps;   (e) mechanical agitation following immersion in the solution; or   (f) application of a primer, prior to immersion in or spraying of a solution.   
     
     
         61 . The method of  claim 60 , wherein the drying is in flow of argon gas or a flow of nitrogen gas. 
     
     
         62 . The composition of  claim 46 , wherein the composition is for use as an anti-fouling agent or for use as an anti-adhesion agent. 
     
     
         63 . The method of  claim 59 , wherein the coated substrate reduces biofouling, reduces adhesion or reduces thrombus formation.