Pharmaceutical composition and health functional food for preventing, ameliorating or treating thrombosis containing extract of vespa velutina nigrithorax as active ingredient

Abstract

An antithrombotic composition containing an extract of Vespa velutina nigrithorax as an active ingredient, and more particularly, a pharmaceutical composition and a health functional food for preventing, ameliorating or treating thrombosis by inhibition of blood coagulation and inhibition of platelet aggregation, which contain an ethyl acetate fraction of an extract of Vespa velutina nigrithorax as an active ingredient. The extract exhibits antithrombotic activity by inhibiting platelet aggregation while exhibiting strong anticoagulant activity by inhibiting thrombosis-related enzymes and blood clotting factors. Also, the extract has no human erythrocyte hemolytic activity, has excellent heat stability, and the thrombosis-related enzyme and blood clotting factor inhibitory effects thereof are not lost even under an acidic condition of pH 2 and in plasma.

What is claimed is: 
     
         1 . A pharmaceutical composition for preventing or treating thrombosis containing an extract of  Vespa velutina nigrithorax  as an active ingredient. 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the extract is an ethanol extract. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the extract is an ethyl acetate fraction obtained after ethanol extraction. 
     
     
         4 . A health functional food for preventing or ameliorating thrombosis containing an extract of  Vespa velutina nigrithorax  as an active ingredient. 
     
     
         5 . The health functional food of  claim 4 , wherein the extract is an ethanol extract. 
     
     
         6 . The health functional food of  claim 4 , wherein the extract is an ethyl acetate fraction obtained after ethanol extraction.