Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase

Abstract

The present invention relates to a compound, 4-amino-N-(1-((3-chloro-2-fluoro-4-hydroxyphenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, and pharmaceutically acceptable salts thereof having inhibitory activity for protein kinases.

What is claimed is: 
     
         1 . A method for preventing or treating a disease mediated by abnormal activation of one or more protein kinases, the method comprising administering an effective amount of the compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof to a mammal in need thereof. 
     
     
         2 . The method of  claim 1 , wherein at least one of said one or more protein kinases is selected from: ALK, AMPK, Aurora A, Aurora B, Aurora C, Axl, Blk, Bmx, BTK, CaMK, CDK2/cyclinE, CDK5/p25, CHK1, CK2, A-RAF, B-RAF, C-RAF, DDR1, DDR2, DMPK, EGFR1, Her2, Her4, EphA1, EphB1, FAK, FGFR2, FGFR3, FGFR4, Flt-1, Flt-3, Flt-4, FMS (CSF-1), Fyn, GSK3 beta, HIPK1, IKK beta, IGFR-1R, IR, Itk, JAK2, JAK3, KDR, Kit, Lck, Lyn, MAPK1, MAPKAP-K2, MEK1, Met, MKK6, MLCK, NEK2, p70S6K, PAK2, PDGFR alpha, PDGFR beta, PDK1, Pim-1, PKA, PKB alpha, PKC alpha, Plk1, Ret, ROCK-I, Rsk1, SAPK 2a, SGK, Src, Syk, Tie-2, Tec, Trk and ZAP-70. 
     
     
         3 . The method of  claim 2  wherein at least one of said one or more protein kinases is selected from: A-RAF, B-RAF, C-RAF, DDR1, DDR2 and FMS. 
     
     
         4 . The method of  claim 1 , wherein said disease is selected from the group consisting of: gastric cancer, lung cancer, liver cancer, colorectal cancer, small intestine cancer, pancreatic cancer, brain cancer, bone cancer, melanoma, breast cancer, sclerosing adenosis, uterine cancer, cervical cancer, head and neck cancer, esophagus cancer, thyroid cancer, parathyroid cancer, renal cancer, sarcoma, prostate cancer, urethral cancer, bladder cancer, blood cancer, lymphoma, fibroadenoma, inflammation, diabetes, obesity, psoriasis, rheumatoid arthritis, hemangioma, acute and chronic kidney disease, coronary restenosis, autoimmune diseases, asthma, neurodegenerative diseases, acute infection and ocular diseases caused by angiogenesis. 
     
     
         5 . The method of  claim 1 , which is used in combination or developed into a combined formulation with a co-drug selected from the group consisting of cell signal transduction inhibitors, mitosis inhibitors, alkylating agents, antimetabolites, antibiotics, growth factor inhibitors, cell cycle inhibitors, topoisomerase inhibitors, biological reaction modifiers, antihormonal agents, antiandrogens, cell differentiation/proliferation/survival inhibitors, apoptosis inhibitors, inflammation inhibitors and P-glycoprotein inhibitors. 
     
     
         6 . The method of  claim 5 , wherein the drug is a signal transduction inhibitor that is a MEK inhibitor.