Nuclear receptor modulators

Abstract

The invention provides compounds of Formula (I)pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

What is claimed: 
     
         1 . A compound of Formula (I) 
       
         
           
           
               
               
           
         
         a pharmaceutically acceptable salt, or a stereoisomer thereof, wherein
 W is C or CR a , L 1  is connected to W or Y; and
 A and E are independently C or N provided both are not N; 
 V is CR 3  or N; 
 X is CR a , NR a , N, or O; 
 Y is C, CR a , NR a , N, O or S; 
 Z is CR 3  or N; or 
 
 W is N or NR a , L 1  is connected to W or Y; and
 A and E are independently C or N provided both are not N; 
 V is CR 3  or N; 
 X is CR a , NR a , or N; 
 Y is C, CR a , or N; 
 Z is CR 3  or N; or 
 
 Cy is a six-membered aromatic, heteroaromatic or partially saturated ring substituted with IV and R 2 ; 
 L 1  is CH(R b )—, —C(R b )(R d )—, —C(O)— or —N(R′)—; 
 L 2  is —C(O)—, —O—, —C(R b )(R d )—, —S—, —S(O)—, —S(O) 2 —; 
 R 1  and R 2  are independently halo, —O—(C 1 -C 3 )alkyl, —O—(C 3 -C 6 )cycloalkyl, optionally substituted (C 3 -C 6 )cycloalkyl, or —(C 1 -C 3 )alkyl; 
 each R 3  is independently H, CF 3 , CN, halo, —C(═O)(C 1 -C 3 )alkyl, —C(O)N(R e ) 2 , —NR e COR e , —OCHF 2 , OCF 3 , —O—(C 1 -C 3 )alkyl, —O—(C 3 -C 6 )cycloalkyl, —S—(C 1 -C 3 )alkyl, optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted heteroaryl or optionally substituted heterocyclyl;
 R 4  is H, —OH, optionally substituted (C 1 -C 6 )alkyl, —NR 5 R 6 , optionally substituted (C 3 -C 6 )cycloalkyl or —(CH 2 ) m -optionally substituted heterocyclyl; 
 wherein R 5  is H or —(C 1 -C 3 )alkyl, and R 6  is optionally substituted (C 1 -C 4 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl or (CH 2 ) m -optionally substituted heterocyclyl; or 
 
 R 5  and R 6 , together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclyl; 
 each R a  is independently H, —C(O)CH 3 , optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl or S(O) 2 -phenyl; 
 each R b  is independently H, F, OH, —O—(C 1 -C 3 )alkyl, or (C 1 -C 3 )alkyl; 
 R c  is independently H or —(C 1 -C 3 )alkyl; 
 each R d  is independently H, F, or (C 1 -C 3 )alkyl; or R d  and R b  form a (C 3 -C 5 ) spirocycle; 
 R e  is independently H or —(C 1 -C 3 )alkyl; and 
 m is independently 0 or 1; 
 provided that not more than two of A, E, W, X and Y are N. 
 
       
     
     
         2 - 31 . (canceled)