Breast prostheses, methods of manufacturing breast prostheses, and methods of treatment using breast prostheses

Abstract

Improved breast prostheses, methods of making breast prostheses, and methods of treatment using such breast prostheses are described.

What is claimed is: 
     
         1 . An implantable prosthesis prepared by a method comprising:
 preparing a shell of a breast implant or tissue expander;   providing one or more samples of graft material sized and shaped to conform to a portion of a surface of the breast implant or tissue expander;   attaching the graft material to the shell of the breast implant or tissue expander prior to curing the shell of the breast implant or tissue expander;   curing the shell of the breast implant or tissue expander and the graft material; and   removing the graft material from the breast implant or tissue expander after the curing step.   
     
     
         2 . The implantable prosthesis of  claim 1 , wherein the graft material is an acellular tissue matrix. 
     
     
         3 . The implantable prosthesis of  claim 2 , wherein the shell of the breast implant or tissue expander and the acellular tissue matrix are cured such that the curing temperature does not reach a temperature greater than 30° C. 
     
     
         4 . The implantable prosthesis of  claim 2 , wherein the shell of the breast implant or tissue expander and the acellular tissue matrix are cured such that the curing temperature does not exceed 25° C. 
     
     
         5 . The implantable prosthesis of  claim 1 , wherein the graft material is an adipose extracellular tissue matrix that has been treated to produce a three-dimensional porous, or sponge-like material. 
     
     
         6 . The implantable prosthesis of  claim 5 , wherein the shell of the breast material or tissue expander and the adipose extracellular tissue matrix are cured at a temperature between 70° C. to 120° C. 
     
     
         7 . The implantable prosthesis of  claim 5 , wherein the shell of the breast material or tissue expander and the adipose extracellular tissue matrix are cured at a temperature between 80° C. to 110° C. 
     
     
         8 . The implantable prosthesis of  claim 5 , wherein the shell of the breast material or tissue expander and the adipose extracellular tissue matrix are cured at 100° C. 
     
     
         9 . The implantable prosthesis of  claim 1 , wherein the graft material is removed from the breast implant or tissue expander after the curing step. 
     
     
         10 . The implantable prosthesis of  claim 1 , wherein the tissue expander or breast implant comprises a saline filled implant. 
     
     
         11 . The implantable prosthesis of  claim 1 , wherein the tissue expander or breast implant comprises a silicone filled implant. 
     
     
         12 . The implantable prosthesis of  claim 1 , wherein the graft material comprises a dermal tissue matrix. 
     
     
         13 . The implantable prosthesis of  claim 1 , wherein the graft material comprises an adipose tissue matrix. 
     
     
         14 . The implantable prosthesis of  claim 1 , wherein the graft material comprises a porcine tissue matrix. 
     
     
         15 . The implantable prosthesis of  claim 1 , wherein the graft material comprises medical grade silicon. 
     
     
         16 . The implantable prosthesis of  claim 1 , wherein the graft material comprises autologous tissue. 
     
     
         17 . The implantable prosthesis of  claim 1 , wherein the graft material comprises cadaveric human tissue. 
     
     
         18 . The implantable prosthesis of  claim 1 , wherein the graft material comprises a single-layered sheet of tissue. 
     
     
         19 . The implantable prosthesis of  claim 1 , wherein the graft material comprises a multi-layered sheet of tissue. 
     
     
         20 . The implantable prosthesis of  claim 1 , wherein the tissue expander or breast implant comprises silicone.