Non-degradable, low swelling, water soluble radiopaque hydrogel polymer

Abstract

Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.

What is claimed is: 
     
         1 - 30 . (canceled) 
     
     
         31 . A method of forming a material in situ comprising:
 providing a delivery system comprising:
 a first container comprising a first water soluble reactive component having a molecular weight between about 200 and about 10,000; 
 a second container comprising a second water soluble reactive component having a molecular weight between about 100 and about 2500; and 
 a delivery tube in fluid communication with the first container and the second container the tube having a first end and a second end; and 
   placing the second end of the delivery tube at a desired space for placement of a solid material;   combining the first water soluble reactive component and second water soluble reactive component to form a mixture;   introducing the mixture into the first end of the delivery tube;   introducing the mixture into the desired space through the delivery tube; and   forming a solid material in the mixture,
 wherein formation of the solid material comprises initiating a chemical reaction of functional groups on said first water soluble reactive component with functional groups on said second water soluble reactive component at a first pH to form said solid material, said chemical reaction consisting essentially of chemical covalent bonding, 
 wherein the mixture comprises a viscosity of between about 20 cp and about 100 cp such that it maintains fluidity upon introduction into the delivery tube in order to travel through the length of the delivery tube, and 
 wherein the solid material comprises a swellability of less than about 30% within about 3 minutes to about 30 minutes of initiating the chemical reaction of the functional groups to form the solid material. 
   
     
     
         32 . The method of  claim 31 , wherein the first pH is at least about 7.4 to form the solid. 
     
     
         33 . The method of  claim 31 , wherein the mixture remains fluid for more than about 3 minutes after formation. 
     
     
         34 . The method of  claim 31 , wherein the first water soluble reactive component comprises an epoxide moiety. 
     
     
         35 . The method of  claim 31 , wherein the second water soluble reactive component comprises at least two amine moieties. 
     
     
         36 . The method of  claim 31 , wherein the solid material comprises a hydrogel. 
     
     
         37 . The method of  claim 31 , further comprising adding an additive to the mixture to increase the cure rate of the material. 
     
     
         38 . The method of  claim 31 , wherein the first or second container is a syringe. 
     
     
         39 . The method of  claim 31 , comprising forming the solid material inside a mammal. 
     
     
         40 . The method of  claim 39 , wherein the solid material is a bulking agent. 
     
     
         41 . A method of forming a material in situ comprising:
 providing a delivery system comprising:
 a first container comprising a first water soluble reactive component having a molecular weight between about 200 and about 10,000; 
 a second container comprising a second water soluble reactive component having a molecular weight between about 100 and about 2500; and 
 a delivery tube in fluid communication with the first container or the second container the tube having a first end and a second end; and 
   placing the second end of the delivery tube at a desired space for placement of a solid material;   combining the first water soluble reactive component and second water soluble reactive component to form a mixture;   introducing the mixture into the first end of the delivery tube;   introducing the mixture into the desired space through the delivery tube; and   forming a hydrogel material in the mixture,
 wherein formation of the hydrogel material comprises initiating a chemical reaction of functional groups on said first water soluble reactive component with functional groups on said second water soluble reactive component at a first pH to form said hydrogel material, said chemical reaction consisting essentially of chemical covalent bonding, 
 wherein the mixture comprises a viscosity of between about 10 cp and about 100 cp such that it maintains fluidity upon introduction into the delivery tube in order to travel through the length of the delivery tube, and 
 wherein the solid material comprises a swellability of less than about 30% within about 3 minutes to about 30 minutes of initiating the chemical reaction of the functional groups to form the solid material. 
   
     
     
         42 . The method of  claim 41 , wherein the first pH is at least about 7.4 to form the solid. 
     
     
         43 . The method of  claim 41 , wherein the mixture remains fluid for more than about 3 minutes after formation. 
     
     
         44 . The method of  claim 41 , wherein the first water soluble reactive component comprises an epoxide moiety. 
     
     
         45 . The method of  claim 41 , wherein the second water soluble reactive component comprises at least two amine moieties. 
     
     
         46 . The method of  claim 41 , wherein the solid material comprises a hydrogel. 
     
     
         47 . The method of  claim 41 , further comprising adding an additive to the mixture to increase the cure rate of the material. 
     
     
         48 . The method of  claim 41 , wherein the first or second container is a syringe. 
     
     
         49 . The method of  claim 41 , comprising forming the solid material inside a mammal. 
     
     
         50 . The method of  claim 49 , wherein the solid material is a bulking agent. 
     
     
         51 . A delivery system for forming a material in situ comprising:
 a first container comprising a first water soluble reactive component having a molecular weight between about 200 and about 10,000;   a second container comprising a second water soluble reactive component having a molecular weight between about 100 and about 2500; and   a delivery tube in fluid communication with the first container and the second container the tube having a first end and a second end; and   the second end of the delivery tube being configured to be placed at a desired space for placement of a solid material;   the first water soluble reactive component and second water soluble reactive component are combinable to form a mixture that can flow from the first end of the delivery tube to the second end of the delivery tube to the desired space for placement of the solid material;   wherein solid material is formed by initiating a chemical reaction of functional groups on said first water soluble reactive component with functional groups on said second water soluble reactive component at a first pH to form said solid material, said chemical reaction consisting essentially of chemical covalent bonding,   wherein the mixture comprises a viscosity of between about 20 cp and about 100 cp such that it maintains fluidity upon introduction into the delivery tube in order to travel through the length of the delivery tube, and   wherein the solid material comprises a swellability of less than about 30% within about 3 minutes to about 30 minutes of initiating the chemical reaction of the functional groups to form the solid material.