Virus-like particle with efficient epitope display

Abstract

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders.

1 . A vaccine for use in the prophylaxis and/or treatment of a disease wherein the vaccine comprises:
 i. a particle-forming polypeptide comprising a first peptide tag, and   ii. an antigen fused to a second peptide tag,   wherein the antigen and particle-forming polypeptide are linked via an isopeptide bond between the first and second peptide tag, and wherein i-ii form a particle displaying said antigen.