Hemostatic sponge

Abstract

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

1 - 10 . (canceled) 
     
     
         11 . A hemostatic composite comprising a hemostatic material and a single hydrophilic polymeric crosslinker, said crosslinker having electrophilic reactive groups, said composite comprising pores which allow external fluids, especially human blood, to access into said composite, wherein said hemostatic material is a non-woven or woven fabric of a hemostatic fiber. 
     
     
         12 . A hemostatic composite according to  claim 11 , wherein said hemostatic material is a fabric of oxidized cellulose. 
     
     
         13 . A hemostatic composite according to  claim 11 , wherein said hydrophilic polymeric crosslinker with electrophilic reactive groups is a polyethylene glycol (PEG) comprising two or more reactive groups selected from the group consisting of succinimidylesters (—CON(COCH 2 ) 2 ), aldehydes (—CHO) and isocyanates (—N═C═O). 
     
     
         14 . A hemostatic composite according to  claim 12 , wherein said hydrophilic polymeric crosslinker with electrophilic reactive groups is a polyethylene glycol (PEG) comprising two or more reactive groups selected from the group consisting of succinimidylesters (—CON(COCH 2 ) 2 ), aldehydes (—CHO) and isocyanates (—N═C═O). 
     
     
         15 . A hemostatic composite according to  claim 12 , wherein said hydrophilic polymeric crosslinker with electrophilic reactive groups is a polyethylene glycol (PEG) comprising two or more reactive succinimidylester (—CON(COCH 2 ) 2 ) groups.