Blood processing cartridges and systems, and methods for extracorporeal blood therapies

Abstract

In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

1 - 163 . (canceled) 
     
     
         164 . A cartridge for use in flow filtration, comprising:
 (a) a housing having a housing interior, a first end, a second end, and a housing body extending from the housing first end to the housing second end, wherein the housing first end includes a dialysate inlet, the housing second end includes a dialysate outlet, the housing body includes a blood inlet and a blood outlet;   (b) a plurality of fibers contained inside said housing in the housing interior, wherein:
 (i) said plurality of fibers comprising a mixture of polyethersulfone and polyvinylpyrrolidone; 
 (ii) at least some of said plurality of fibers being hollow and being made of semi-permeable membranes having respective fiber interiors and fiber exteriors; 
 (iii) the fiber exteriors being smoother than the fiber interiors; 
 (iv) said plurality of fibers being parallel or almost parallel to each other over at least a substantial portion of their lengths; 
 (v) said fiber exteriors have a hemocompatible exterior surface wherein the hemocompatible exterior surface is wettable by water without substantial hydrophobic patches; and 
   (c) a first end barrier that joins with said plurality of fibers at first ends of said plurality of fibers and joins with a said housing interior and bounds a first end plenum and separates said first end plenum from a housing midsection interior region;   (d) a second end barrier that joins with said plurality of fibers at second ends of said plurality of fibers and joins with said housing interior and bounds a second end plenum and separates said second end plenum from said housing midsection interior region;   (e) a first fluid flow compartment comprising said first end plenum and said fiber interiors and said second end plenum, said first end plenum and said fiber interiors and said second end plenum being in fluid communication with each other; and   (f) a second fluid flow compartment comprising the inter fiber space and the blood inlet and the blood outlet, all in fluid communication with each other, wherein said second fluid flow compartment comprises a supply distributor inside said housing near said blood inlet, and a discharge distributor inside said housing near said blood outlet, wherein said supply distributor and said discharge distributor are each constructed to introduce or discharge blood to or from said fiber exteriors substantially 360 degrees around a circumference of said plurality of fibers to create uniform or quasi uniform blood flow in the inter fiber space.   
     
     
         165 . The cartridge of  claim 164 , wherein an axial length of said discharge distributor is shorter than an axial length of said supply distributor. 
     
     
         166 . The cartridge of  claim 164 , wherein a flow entrance region length of said discharge distributor is shorter than a flow entrance region length of said supply distributor. 
     
     
         167 . The cartridge of  claim 164 , wherein an axial length of a flow transition region near said blood outlet is shorter than an axial length of a flow transition region near said blood inlet. 
     
     
         168 . The cartridge of  claim 164 , wherein near said blood inlet of said cartridge, said plurality of fibers fan at a supply end fanning angle greater than zero, and near said blood outlet of said cartridge, said plurality of fibers do not fan. 
     
     
         169 . The cartridge of  claim 164 , wherein near said blood inlet of said cartridge, said plurality of fibers fan having a supply end fanning area ratio greater than zero, and near said blood outlet of said cartridge, said plurality of fibers do not fan. 
     
     
         170 . The cartridge of  claim 164 , wherein near said blood inlet of said cartridge, said plurality of fibers fan having a supply end fanning ratio, and near said blood outlet of said cartridge, said plurality of fibers fan having a discharge end fanning ratio that is smaller than said supply end fanning ratio. 
     
     
         171 . The cartridge of  claim 164 , wherein near said blood inlet of said cartridge, said plurality of fibers fan having a supply end fanning length, and near said blood outlet end of said cartridge, said plurality of fibers fan having a discharge end fanning length that is smaller than said supply end fanning length. 
     
     
         172 . The cartridge of  claim 164 , wherein at least some of said plurality of fibers have an outside diameter that is in the range of 100 microns to 300 microns. 
     
     
         173 . The cartridge of  claim 164 , wherein at least some of said plurality of fibers are wavy fibers. 
     
     
         174 . The cartridge of  claim 164 , wherein said plurality of fibers have a porosity in the inter fiber space of between 40% and 70%. 
     
     
         175 . The cartridge of  claim 164 , wherein said plurality of fibers have a porosity in the inter fiber space of between 50% and 62%. 
     
     
         176 . The cartridge of  claim 164 , wherein said supply and discharge distributors have respective axial lengths L, and said housing midsection interior region has a radius r, and said supply distributor has a value of 2*L/r that is greater than 1.0, and said discharge distributor has a value of 2*L/r that is less than 1.0. 
     
     
         177 . The cartridge of  claim 164 , wherein said plurality of fibers, near said discharge distributor, serves as an emboli trap. 
     
     
         178 . The cartridge of  claim 164 , wherein said fiber exteriors have a root-mean-square surface roughness of less than 100 nanometers. 
     
     
         179 . The cartridge of  claim 164 , wherein near said supply distributor said plurality of fibers fan having a supply end fanning angle, and near said discharge distributor said plurality of fibers have a discharge fanning angle that is smaller than the supply end fanning angle.