Substituted Imidazo[4,5-c]pyridine Compounds and Compositions Thereof

Abstract

Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity:where V, W, X, Y, Z, R1, and R3 are as defined herein.

1 - 18 . (canceled) 
     
     
         19 . A compound having a structure represented by a formula: 
       
         
           
           
               
               
           
         
         wherein Y is selected from hydrogen, hydroxyl, —NH 2 , —NH(C1-C4 alkyl), —NH(C1-C4 haloalkyl), and C1-C4 alkoxy; 
         wherein Z is selected from hydrogen, halogen, hydroxyl, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, —CONH 2 , —SO 2 NH 2 , —NH 2 , —NH(C1-C4 alkyl), and —NH(C1-C4 haloalkyl); 
         wherein R 1  is a phenyl ring, or a 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, C1-C4 alkyl, and C1-C4 haloalkyl; 
         wherein W is a phenyl ring or a 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, cyano, C1-C4 alkyl, and C1-C4 haloalkyl; 
         wherein V is a bond; 
         wherein R 3  is a structure selected from: 
       
       
         
           
           
               
               
           
         
          and
 wherein R 8 , when present, is selected from hydrogen, CH 3 , —CONH 2 , —NHCONH 2 , —S(O) 2 CH 3 , and —COCH 3 , 
 
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         20 . The compound of  claim 19 , wherein Y is hydrogen. 
     
     
         21 . The compound of  claim 19 , wherein Z is hydrogen. 
     
     
         22 . The compound of  claim 19 , wherein R 1  is phenyl or 6-membered heteroaryl, and wherein R 1  is substituted with one substituent selected from halogen, C 1-4 -alkyl, and halo-C 1-4 -alkyl. 
     
     
         23 . The compound of  claim 19 , wherein W is a phenyl ring or wherein W is a 6-membered heterocyclic ring selected from pyridine, pyridazine, pyrazine, and pyrimidine. 
     
     
         24 . The compound of  claim 19 , wherein W is substituted with one or more substituents selected from fluoro, chloro, cyano, CH 3 , and CF 3 . 
     
     
         25 . The compound of  claim 19 , wherein each of Y and Z is hydrogen. 
     
     
         26 . The compound of  claim 19 , wherein R 1  is a structure: 
       
         
           
           
               
               
           
         
       
     
     
         27 . The compound of  claim 19 , wherein W is unsubstituted. 
     
     
         28 . The compound of  claim 19 , wherein W is unsubstituted pyridinyl. 
     
     
         29 . The compound of  claim 19 , wherein W is a structure: 
       
         
           
           
               
               
           
         
       
     
     
         30 . The compound of  claim 19 , wherein R 3  is a structure selected from: 
       
         
           
           
               
               
           
         
       
     
     
         31 . The compound of  claim 19 , wherein the compound has a structure represented by a formula: 
       
         
           
           
               
               
           
         
       
     
     
         32 . The compound of  claim 19 , wherein the compound has a structure represented by a formula: 
       
         
           
           
               
               
           
         
       
     
     
         33 . The compound of  claim 19 , wherein the compound is selected from: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof.