US2023112453A1PendingUtilityA1

Methods and materials for treating hypocapnia

63
Assignee: MAYO FOUND MEDICAL EDUCATION & RESPriority: Jun 28, 2017Filed: Dec 13, 2022Published: Apr 13, 2023
Est. expiryJun 28, 2037(~10.9 yrs left)· nominal 20-yr term from priority
Inventors:Jan StepanekMichael J. CevetteGaurav N. PradhanSamantha J. KleindienstJamie M. BogleRebecca S. BlueKaren K. Breznak
A61M 2205/8231A61M 2202/0225A61M 2202/0208A61P 11/00A61M 16/12A61P 3/00A61K 9/0007A61K 9/0056A61M 16/0045A61M 16/06A61M 16/0683
63
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Claims

Abstract

This document provides methods and materials for treating hypocapnia. For example, methods and materials for delivering CO2 to a mammal to treat hypocapnia or compensate for a reduced level of CO2 are provided.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition, wherein at least 90 percent of said composition comprises an acid and a carbonate, wherein said composition releases CO 2  for a mammal to inhale once said composition is placed within a cup with liquid. 
     
     
         2 . The composition of  claim 1 , wherein said mammal is a human. 
     
     
         3 . The composition of  claim 1 , wherein said acid is ascorbic acid. 
     
     
         4 . The composition of  claim 1 , wherein said acid is acetic acid, tartaric acid, malic acid, citric acid, monosodium citric acid, disodium citric acid, anhydrous citric acid, fumaric acid, or glutaric acid. 
     
     
         5 . The composition of  claim 1 , wherein said carbonate is sodium bicarbonate. 
     
     
         6 . The composition of  claim 1 , wherein said carbonate is potassium bicarbonate. 
     
     
         7 . The composition of  claim 1 , wherein said carbonate is magnesium bicarbonate. 
     
     
         8 . The composition of  claim 1 , wherein said carbonate is in dry form. 
     
     
         9 . The composition of  claim 1 , wherein at least 95 percent of said composition comprises said acid and said carbonate. 
     
     
         10 . The composition of  claim 1 , wherein said composition releases said CO 2  in a non-exothermic manner. 
     
     
         11 . The composition of  claim 1 , wherein said acid is ascorbic acid, and wherein said carbonate is sodium bicarbonate. 
     
     
         12 . The composition of  claim 11 , wherein said ascorbic acid is in dry form. 
     
     
         13 . The composition of  claim 11 , wherein said sodium bicarbonate is in dry form. 
     
     
         14 . The composition of  claim 1 , wherein said liquid is water. 
     
     
         15 . The composition of  claim 1 , wherein said composition comprises a coating. 
     
     
         16 . The composition of  claim 15 , wherein said coating comprises shellac and polyvinyl pyrrolidone. 
     
     
         17 . The composition of  claim 15 , wherein said coating comprises polyvinyl acetate phthalate. 
     
     
         18 . The composition of  claim 15 , wherein said coating comprises cellulose acetate phthalate. 
     
     
         19 . The composition of  claim 15 , wherein said coating comprises an acrylate polymer. 
     
     
         20 . The composition of  claim 1 , wherein said composition comprises a sugar coating. 
     
     
         21 . The composition of  claim 1 , wherein said composition is a tablet. 
     
     
         22 . The composition of  claim 21 , wherein said tablet comprises about 500 mg to about 2000 mg of anhydrous citric acid in solid form and from about 958 mg to about 3,832 mg of sodium bicarbonate in solid form. 
     
     
         23 . The composition of  claim 1 , wherein said composition releases about 1 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         24 . The composition of  claim 1 , wherein said composition comprises about 100 mg of anhydrous citric acid in solid form and about 191.6 mg of sodium bicarbonate in solid form. 
     
     
         25 . The composition of  claim 1 , wherein said composition releases about 3 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         26 . The composition of  claim 1 , wherein said composition comprises about 300 mg of anhydrous citric acid in solid form and about 574.8 mg of sodium bicarbonate in solid form. 
     
     
         27 . The composition of  claim 1 , wherein said composition releases about 5 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         28 . The composition of  claim 1 , wherein said composition comprises about 500 mg of anhydrous citric acid in solid form and about 958 mg of sodium bicarbonate in solid form. 
     
     
         29 . The composition of  claim 1 , wherein a surface of said composition comprises a printed indication of amount of said CO 2  expected to be released. 
     
     
         30 . The composition of  claim 1 , wherein said composition comprises a pharmaceutically acceptable carrier. 
     
     
         31 . The composition of  claim 1 , wherein said composition is in the form of a sustained-release formulation, a tablet, a capsule, or a pill. 
     
     
         32 . A capsule device for delivering CO 2  to a mammal, wherein said capsule device comprises a liquid compartment for housing a liquid, a solid compartment for housing a solid, an actuator configured to allow said liquid, when present in said liquid compartment, to contact said solid, when present in said solid compartment, upon actuation, and a mouthpiece portion, wherein said contact of said liquid, when present, with said solid, when present, releases CO 2  for said mammal to inhale through said mouthpiece. 
     
     
         33 . The capsule device of  claim 32 , wherein said mammal is a human. 
     
     
         34 . The capsule device of  claim 32 , wherein said liquid is an acid. 
     
     
         35 . The capsule device of  claim 34 , wherein said acid is ascorbic acid. 
     
     
         36 . The capsule device of  claim 32 , wherein said solid is a carbonate. 
     
     
         37 . The capsule device of  claim 36 , wherein said carbonate is sodium bicarbonate. 
     
     
         38 . The capsule device of  claim 32 , wherein said capsule device comprises said liquid within said liquid compartment. 
     
     
         40 . The capsule device of  claim 38 , wherein said liquid is an acid. 
     
     
         41 . The capsule device of  claim 40 , wherein said acid is ascorbic acid. 
     
     
         42 . The capsule device of  claim 32 , wherein said capsule device comprises said solid within said solid compartment. 
     
     
         43 . The capsule device of  claim 42 , wherein said solid is a carbonate. 
     
     
         44 . The capsule device of  claim 43 , wherein said carbonate is sodium bicarbonate. 
     
     
         45 . A method for delivering CO 2  to a mammal, wherein said method comprises placing a composition into a container with a liquid, wherein at least 90 percent of said composition comprises an acid and a carbonate, wherein, upon contact with said liquid, said composition releases CO 2  for said mammal to inhale from said container, thereby providing said mammal with CO 2 . 
     
     
         46 . The method of  claim 45 , wherein said mammal is a human. 
     
     
         47 . The method of  claim 45 , wherein said acid is ascorbic acid. 
     
     
         48 . The method of  claim 45 , wherein said acid is acetic acid, tartaric acid, malic acid, citric acid, monosodium citric acid, disodium citric acid, anhydrous citric acid, fumaric acid, or glutaric acid. 
     
     
         49 . The method of  claim 45 , wherein said carbonate is sodium bicarbonate. 
     
     
         50 . The method of  claim 45 , wherein said carbonate is potassium bicarbonate. 
     
     
         51 . The method of  claim 45 , wherein said carbonate is magnesium bicarbonate. 
     
     
         52 . The method of  claim 45 , wherein said carbonate is in dry form. 
     
     
         53 . The method of  claim 45 , wherein at least 95 percent of said composition comprises said acid and said carbonate. 
     
     
         54 . The method of  claim 45 , wherein said composition releases said CO 2  in a non-exothermic manner. 
     
     
         55 . The method of  claim 45 , wherein said acid is ascorbic acid, and wherein said carbonate is sodium bicarbonate. 
     
     
         56 . The method of  claim 55 , wherein said ascorbic acid is in dry form. 
     
     
         57 . The method of  claim 55 , wherein said sodium bicarbonate is in dry form. 
     
     
         58 . The method of  claim 45 , wherein said liquid is water. 
     
     
         59 . The method of  claim 45 , wherein said composition comprises a coating. 
     
     
         60 . The method of  claim 59 , wherein said coating comprises shellac and polyvinyl pyrrolidone. 
     
     
         61 . The method of  claim 59 , wherein said coating comprises polyvinyl acetate phthalate. 
     
     
         62 . The method of  claim 59 , wherein said coating comprises cellulose acetate phthalate. 
     
     
         63 . The method of  claim 59 , wherein said coating comprises an acrylate polymer. 
     
     
         64 . The method of  claim 45 , wherein said composition comprises a sugar coating. 
     
     
         65 . The method of  claim 45 , wherein said composition is a tablet. 
     
     
         66 . The method of  claim 65 , wherein said tablet comprises about 500 mg to about 2000 mg of anhydrous citric acid in solid form and from about 958 mg to about 3,832 mg of sodium bicarbonate in solid form. 
     
     
         67 . The method of  claim 45 , wherein said composition releases about 1 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         68 . The method of  claim 45 , wherein said composition comprises about 100 mg of anhydrous citric acid in solid form and about 191.6 mg of sodium bicarbonate in solid form. 
     
     
         69 . The method of  claim 45 , wherein said composition releases about 3 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         70 . The method of  claim 45 , wherein said composition comprises about 300 mg of anhydrous citric acid in solid form and about 574.8 mg of sodium bicarbonate in solid form. 
     
     
         71 . The method of  claim 45 , wherein said composition releases about 5 percent CO 2  for inhalation at a normal ventilation rate of about 15 breaths per minute, at a depth of about 500 mL per breath, and at about 100% reaction efficiency. 
     
     
         72 . The method of  claim 45 , wherein said composition comprises about 500 mg of anhydrous citric acid in solid form and about 958 mg of sodium bicarbonate in solid form. 
     
     
         73 . The method of  claim 45 , wherein a surface of said composition comprises a printed indication of amount of said CO 2  expected to be released. 
     
     
         74 . The method of  claim 45 , wherein said composition comprises a pharmaceutically acceptable carrier. 
     
     
         75 . The method of  claim 45 , wherein said composition is in the form of a sustained-release formulation, a tablet, a capsule, or a pill.

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