Synergistic compositions for improving brain health

Abstract

The invention discloses synergistic herbal compositions comprising the first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Terminalia chebula in combination with a second ingredient selected from the oil extract(s)/fraction(s) derived from Boswellia serrata gum resin for improving atleast one cognitive functions selected from memory, intelligence, learning, recall information/communication, focus, concentration, reasoning, problem solving, decision making and mental fatigue.

1 . Synergistic herbal compositions comprising a first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from  Terminalia chebula  in combination with a second ingredient selected from the oil extract(s)/fraction(s) derived from  Boswellia serrata  gum resin, after removing boswellic acids, for improving at least one cognitive function selected from memory, intelligence, learning, retention, recall information/communication, focus, concentration, attention, perception, reasoning, problem solving, decision making and mental fatigue. 
     
     
         2 . The synergistic compositions as claimed in  claim 1 , wherein the compositions contain  Terminalia chebula  extract standardized to at least one compound selected from chebulagic acid, chebulinic acid, gallic acid and ellagic acid; and  Boswellia serrata  oil excluding boswellic acids, standardized to at least one compound selected from epi-a-amyrin, epi-β-amyrin and a-amyrin. 
     
     
         3 . The synergistic compositions as claimed in  claim 1 , wherein the compositions contain optionally at least one additional component selected from the group consisting of biological agent(s), and Nootropic agent(s); pharmaceutically acceptable active ingredients, vitamins, minerals; pharmaceutically or nutraceutically or dietically acceptable, excipients, carriers or diluents. 
     
     
         4 . The synergistic compositions as claimed in  claim 3 , wherein the pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents are selected from monosaccharide's such as glucose, dextrose, fructose, galactose etc.; Disaccharides such as but not limited to sucrose, maltose, lactose, lactulose, trehalose cellobiose, chitobiose etc.; Poly carbohydrates such as Starch and modified starch such as Sodium starch glycolate, pre gelatinized starch, soluble starch, and other modified starches such as but not limited to Ultrasperse A & Ultra-tex 4; Dextrins that are produced by hydrolysis of starch or glycogen such as yellow dextrin, white dextrin, Maltodextrin etc.; Polyhydric alcohols or sugar alcohols such as but not limited to Sorbitol, mannitol, inositol, xylitol, isomalt etc.; cellulose based derivatives such as but not limited to microcrystalline cellulose, hydroxy propyl methyl cellulose, hydroxy ethyl cellulose, sodium carboxy methyl cellulose (sodium CMC) etc.; silicates such as but not limited to neusilin, veegum, Talc, colloidal silicon dioxide etc.; metallic stearates such as but not limited to calcium stearate, magnesium stearate, zinc Stearate etc.; Organic acids such as citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid etc.; Fatty acid esters and esters of poly sorbate, natural gums such as but not limited to acacia, carrageenan, Guar gum, Xanthan gum etc.; vitamin B group, nicotinamide, calcium pantothenate, amino acids, proteins such as but not limited to casein, gelatin, pectin, agar; organic metal salts such as but not limited to sodium chloride, calcium chloride, dicalcium phosphate, magnesium hydroxide, zinc Sulphate, zinc chloride etc.; Natural pigments, flavors, Class I & Class II preservatives and aqueous, alcoholic, hydro-alcoholic, organic solutions of above listed ingredients alone or in combination. 
     
     
         5 . The synergistic composition as claimed in  claim 1 , where in the composition is formulated into a dosage form selected from dry powder form, liquid form, beverage, food product, dietary supplement or any suitable form such as tablet, a capsule, a soft chewable tablet or gummy bear. 
     
     
         6 . The synergistic composition as claimed in  claim 1 , where in the composition is formulated into nutritional/dietary supplements that can be contemplated/made into the dosage form of healthy foods, or food for specified health uses such as solid food like chocolate or nutritional bars, semisolid food like cream, jam, or gel or beverage such as refreshing beverage, lactic acid bacteria beverage, drop, candy, chewing gum, gummy candy, yoghurt, ice cream, pudding, soft adzuki bean jelly, jelly, cookie, tea, soft drink, juice, milk, coffee, cereal, snack bar. 
     
     
         7 . The synergistic compositions as claimed in  claim 1 , wherein the extract, fraction, active compound or phytochemical is obtained from at least one plant part selected from the group consisting of leaves, stems, tender stems, tender twigs, aerial parts, whole fruit, fruit rind, seed, root, bark, bulb, hardwood, gum resin or whole plant or mixtures thereof. 
     
     
         8 . The synergistic compositions as claimed in  claim 1 , wherein the extract, fraction, active compound or phytochemical are produced using at least one solvent selected from but not limited to C1-C5 alcohols like ethanol, methanol, n-propanol, isopropyl alcohol; ketones like acetone, methylisobutyl ketone, chlorinated solvents like methylene dichloride and chloroform, water and mixtures thereof; C1-C7 hydrocarbons such as hexane; esters like ethyl acetate and the like and mixtures thereof. 
     
     
         9 . The synergistic herbal compositions comprising a first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from  Terminalia chebula  in combination with a second ingredient selected from the oil extract(s)/fraction(s) derived from  Boswellia serrata  gum resin, as claimed in  claim 1 , where in the weight of the first ingredient varies in the range of 10%-90% and the weight of the second ingredient varies in the range of 90% -10% in the composition. 
     
     
         10 . The Synergistic herbal composition as claimed in  claim 1 , wherein the composition is standardized to at least one  Terminalia chebula  marker compound selected from gallic acid, ellagic acid, chebulagic acid, chebulinic acid and at least one  Boswellia serrata  gum resin marker compound selected from serratol, epi-a-amyrin, epi-β-amyrin and a-amyrin; wherein the markers of each of  Terminalia chebula  and  Boswellia serrata  gum resin in the composition is in the range of 0.1 to 50% by weight of the composition. 
     
     
         11 . A method of improving at least one cognitive function selected from memory, intelligence, learning, retention, recall information/communication, focus, concentration, attention, perception, reasoning, problem solving, decision making and mental fatigue in a human, wherein the method comprises supplementing the human with an effective dose of a composition comprising a first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from  Terminalia chebula  in combination with a second ingredient selected from the oil extract(s)/fraction(s) derived from  Boswellia serrata  gum resin, after removing boswellic acids, and optionally containing at least one component selected from pharmaceutically or nutraceutically or dietically acceptable excipients, carriers, diluents, biological agent(s) and Nootropic agent(s). 
     
     
         12 . (canceled)