Composition containing perilla frutescens fermented extract for prevention, alleviation, or treatment of sleep disorder

Abstract

A pharmaceutical composition, a dietary supplement, or food containing a Perilla frutescens fermented extract is disclosed. The composition is useful for prevention or treatment of a sleep disorder. A composition or a fiber or fragrance composition containing a Perilla frutescens fermented extract is also disclosed. A method for treating sleep disorder employing the pharmaceutical composition, dietary supplement, food, or the fiber or fragrance composition is disclosed.

1 . A composition comprising a  Perilia   frutescens  fermented extract, wherein the  Perilla   frutescens  fermented extract is obtained by subjecting an extract of  Perilla   frutescens  with water, a C 1  to C 4  organic solvent, or a mixture thereof as a solvent, to a fermentation employing a fermentation microorganism comprising any one or more strains selected from the group consisting of  bacillus   subtilis ,  lactobacillus  rhamnosus, and  Saccharomyces   cerevisiae . 
     
     
         2 . The composition of  claim 1 , wherein the fermented extract is extracted from any one or more sites selected from the group consisting of leaves, stems, flowers, fruit, and seeds of  Perilla   frutescens . 
     
     
         3 . The composition of  claim 1 , wherein the fermentation is performed at 5° C. to 80° C. for 30 minutes to 10 days. 
     
     
         4 . The composition of  claim 1 , which is a food composition or a dietary supplement, and further comprises an additive selected from the group consisting of a vitamin, an electrolyte, a flavoring agent, a colorant, a filler, a pectic acid and a salt thereof, an alginic acid and a salt thereof, an organic acid, a protective colloid thickener, a pH adjusting agent, a stabilizer, an antiseptic, glycerin, an alcohol, a carbonating agent, a dietary fiber, fruit pulp, and a combination thereof. 
     
     
         5 . The composition of  claim 4 , wherein the food composition is a beverage or a solid food. 
     
     
         6 . The composition of  claim 5 , wherein the food composition comprises dietary fiber, vitamins, or a combination thereof, as the additive. 
     
     
         7 . The composition of  claim 5 , wherein the beverage is a carbonated beverage and comprises a carbonating agent. 
     
     
         8 . The composition of  claim 5 , wherein the solid food is a sausage, bread, biscuit, rice cake, chocolate, candy, confectionery, pizza, instant noodle, fresh noodle, chewing gum, a dairy product, or a combination thereof. 
     
     
         9 . The composition of  claim 4 , wherein the composition is in a solid preparation selected from a tablet, a pill, a powder, a granule, a capsule, or a combination thereof. 
     
     
         10 . The composition of  claim 4 , wherein the composition is in a liquid preparation selected from a suspension, an emulsion, a syrup, a soup, or a combination thereof. 
     
     
         11 . The composition of  claim 1 , which is a sleep aid formulation.