US2023119275A1PendingUtilityA1

Drug effective for lymphogenous drug administrating method

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Assignee: UNIV TOHOKUPriority: Oct 5, 2016Filed: Dec 8, 2022Published: Apr 20, 2023
Est. expiryOct 5, 2036(~10.2 yrs left)· nominal 20-yr term from priority
Inventors:Tetsuya KodamaShiro MoriGo Nohara
A61K 31/4745A61K 31/337A61P 35/00A61K 45/00A61K 31/513A61K 31/437A61K 45/06
62
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Claims

Abstract

Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition for administration into a lymph node for therapeutic or prophylactic treatment of cancer, comprising at least one anticancer drug comprising 5-fluorouracil (5-FU). 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition comprises 1 ng to 100 mg of 5-FU. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition has a viscosity of 40 mPa·s or less. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition has a viscosity of 1 to 10 mPa·s. 
     
     
         5 . A method of manufacturing a pharmaceutical composition for administration into a lymph node for therapeutic or prophylactic treatment of cancer, the method comprising:
 adding at least one anticancer drug comprising 5-FU to a composition.   
     
     
         6 . The method of  claim 5 , wherein the pharmaceutical composition comprises 1 ng to 100 mg of 5-FU. 
     
     
         7 . The method of  claim 5 , wherein the pharmaceutical composition has a viscosity of 40 mPa·s or less. 
     
     
         8 . The method of  claim 5 , wherein the pharmaceutical composition has a viscosity of 1 to 10 mPa·s or less. 
     
     
         9 . A method for therapeutically or prophylactically treating cancer, the method comprising:
 administering a pharmaceutical composition comprising at least one anticancer drug comprising 5-FU into a lymph node of a patient.   
     
     
         10 . The method of  claim 9 , wherein the lymph node is a lymph node suitable for therapeutic treatment or a lymph node positioned upstream in a lymphatic network to which the lymph node belongs. 
     
     
         11 . The method of  claim 9 , wherein the pharmaceutical composition comprises from 1 ng to 100 mg of 5-FU. 
     
     
         12 . The method of  claim 9 , wherein the pharmaceutical composition has a viscosity of 40 mPa·s or less. 
     
     
         13 . The method of  claim 9 , wherein the pharmaceutical composition has a viscosity of 1 to 10 mPa·s or less.

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