PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY

Abstract

Provided herein are Heteroaryl Compounds having the following structure: wherein R 1 -R 4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

1 - 20 . (canceled) 
     
     
         21 . A method for preparing a compound of formula (III), 
       
         
           
           
               
               
           
         
         the method comprising contacting a compound of formula (IV) 
       
       
         
           
           
               
               
           
         
         with R 2 —NH 2  in a solvent, in the presence of a base, wherein 
         R 2  is substituted or unsubstituted C 1-8  alkyl, 
         R 3  and R 4  are H, 
         X is a halogen, 
         Hal is a halogen, and 
         Hal 2  is Br or I. 
       
     
     
         22 . The method of claim  1 , wherein the solvent as acetonitrile or tetrahydrofuran. 
     
     
         23 . The method of claim  1 , wherein the base is triethylamine or diisopropylethylamine. 
     
     
         24 . The method of claim  1 , wherein halogen is Br 
     
     
         25 . The method of claim  1 , wherein Hal 2  is Br.