Base Composition for Tape Agent

Abstract

The present invention provides a composition for a non-aqueous patch preparation having an excellent adhesibility which can sustainedly release a drug. The patch preparation of the present invention can improve the adhesibility thereof as well as the release property of a drug by the addition of powder ingredient (e.g. a filler). As a result, the long-time sustention of the adhesibility of patch preparations can achieve the improvement of the transdermal absorbability and the sustained release of a drug. By the use of a composition for a patch preparation comprising this powder ingredient, a drug, regardless of the type of a drug is dissolved in an organic solvent or an ionic liquid to prepare a drug solution comprising the organic solvent, the drug solution is incorporated into the non-aqueous patch preparation of the present invention, and thereby a preparation with the improved transdermal-absorbability and sustained release can prepared.

1 - 12 . (canceled) 
     
     
         13 . A composition for a non-aqueous patch preparation comprising a drug, an organic solvent, and a powder which is insoluble both in the organic solvent and in a lipophilic plaster base material, wherein the organic solvent is at least one selected from an alcohol, a polyalcohol, an ester, or combinations thereof, the powder is anhydrous silicic acid, and the powder for an adhesive layer is contained as shown in the following inequality:
   0.2×(the weight of the adhesive layer)×(the bulk density of the powder)≤the amount of the powder to be added≤0.6×(the weight of the adhesive layer)×(the tap density of the powder).
   
     
     
         14 . The composition according to  claim 13 , wherein the organic solvent is at least one selected from oleyl alcohol, propylene glycol, 1,3-butane diol, polyethylene glycol, glycerine, or a combinations thereof. 
     
     
         15 . The composition according to  claim 13 , wherein the composition comprises a fatty acid-based ionic liquid. 
     
     
         16 . The composition according to  claim 15 , wherein the fatty acid-based ionic liquid comprises a saturated or unsaturated fatty acid having 3 to 22 carbon atoms. 
     
     
         17 . The composition according to  claim 16 , wherein the saturated or unsaturated fatty acid having 3 to 22 carbon atoms is at least one selected from the group consisting of lactic acid, levulinic acid, decanoic acid, oleic acid, isostearic acid, and myristic acid. 
     
     
         18 . The composition according to  claim 13 , wherein the drug is a drug with a hydrophilic residue. 
     
     
         19 . The composition according to  claim 13 , wherein the lipophilic plaster base material comprises an elastomeric styrene-isoprene-styrene block copolymer. 
     
     
         20 . The composition according to  claim 13 , wherein the drug is selected from a small molecular medicinal compound, a protein medicine, an antigen peptide, or a nucleic acid derivative. 
     
     
         21 . The composition according to  claim 13 , wherein the organic solvent is contained as shown in the following inequality:
 the amount of the solvent to be added   (the volume of the solvent to be added)   
       
         
           
             
               < 
               
                 
                   
                     the 
                     ⁢ 
                         
                     amount 
                     ⁢ 
                         
                     of 
                     ⁢ 
                         
                     the 
                     ⁢ 
                          
                     powder 
                     ⁢ 
                         
                     to 
                     ⁢ 
                         
                     be 
                     ⁢ 
                         
                     added 
                   
                   
                     
                       
                         
                           the 
                           ⁢ 
                               
                           tap 
                           ⁢ 
                               
                           density 
                           ⁢ 
                               
                           of 
                           ⁢ 
                               
                           the 
                           ⁢ 
                               
                           powder 
                         
                       
                     
                     
                       
                         
                           
                             ( 
                             
                               the 
                               ⁢ 
                                   
                               volume 
                               ⁢ 
                                   
                               of 
                               ⁢ 
                                   
                               the 
                               ⁢ 
                                    
                               powder 
                               ⁢ 
                                   
                               to 
                               ⁢ 
                                   
                               be 
                               ⁢ 
                                   
                               added 
                             
                             ) 
                           
                           . 
                         
                       
                     
                   
                 
                 × 
                 
                   1.2 
                   .