The use of menthol for the preparation of a topical composition to improve neurodegenerative disease and stroke

Abstract

The use of menthol or an isomer thereof for preparation of a topical composition to improve neurodegenerative diseases and stroke wherein the neurodegenerative diseases are attributed to cerebral neurons impaired or degenerated, shortage of dopamine in a brain. The topical composition is manufactured as patches, liquids, pastes, oily substances, powders, gels, sprays, composite products or other products to be covered on limbs and applied on skin. A product to be covered on limbs can be a glove, a foot muff, a sock or an extended part or a layered object from a garment for continuous contact between skin and menthol. The present invention also provides the use of menthol or an isomer thereof for preparation of a topical composition to improve diseases or symptoms attributed to cerebral neurons impaired or degenerated, shortage of dopamine or stroke.

1 . A method of improving neurodegenerative diseases and stroke, the method comprising administering to a subject in need thereof a therapeutically effective amount of a topical composition comprising menthol or an isomer. 
     
     
         2 . The method according to  claim 1 , wherein the isomer of menthol is a structural isomer or a stereoisomer. 
     
     
         3 . The method according to  claim 1 , wherein the menthol or the isomer thereof in the topical composition features a weight percentage ranging from 1% to 20%. 
     
     
         4 . The method according to  claim 1 , wherein the topical composition is administrated once or twice per day. 
     
     
         5 . The method according to  claim 1 , wherein the topical composition is manufactured as patches, liquids, pastes, oily substances, powders, gels, sprays, composite products or other products to be covered on limbs and applied on skin. 
     
     
         6 . The method according to  claim 5 , wherein a product to be covered on limbs can be a glove, a foot muff, a sock or an extended part or a layered object from a garment. 
     
     
         7 . The method according to  claim 5 , wherein a product to be covered on limbs is manufactured for continuous contact between skin and menthol. 
     
     
         8 . The method according to  claim 1 , wherein the neurodegenerative diseases are attributed to cerebral neurons impaired or degenerated or shortage of dopamine in a brain. 
     
     
         9 . The method according to  claim 1 , wherein one of the neurodegenerative diseases is Parkinson's disease or Alzheimer's disease and the stroke is ischemic stroke. 
     
     
         10 . The method according to  claim 1 , wherein the topical composition is used to improve symptoms attributed to cerebral neurons impaired or degenerated, shortage of dopamine or stroke and including, without limitation, cognitive dysfunction, ataxia, depression, weakness of limbs, hemiplegia, headache, vertigo, aphasia or alalia, blurring of vision or visual impairment, palpitation, convulsion, nausea and vomiting, fatigue, drooling, dysphagia, facial paralysis and incontinence. 
     
     
         11 . A method of improving diseases or symptoms attributed to cerebral neurons impaired or degenerated, the method comprising administering to a subject in need thereof a therapeutically effective amount of a topical composition comprising menthol or an isomer. 
     
     
         12 . A method of improving diseases or symptoms attributed to shortage of dopamine in a brain, the method comprising administering to a subject in need thereof a therapeutically effective amount of a topical composition comprising menthol or an isomer. 
     
     
         13 . A method of improving diseases or symptoms attributed to stroke, the method comprising administering to a subject in need thereof a therapeutically effective amount of a topical composition comprising menthol or an isomer.