US2023135101A1PendingUtilityA1

Bioabsorbable polymeric composition for a medical device

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Assignee: ORBUSNEICH MEDICAL PTE LTDPriority: Jul 20, 2006Filed: Dec 23, 2022Published: May 4, 2023
Est. expiryJul 20, 2026(expired)· nominal 20-yr term from priority
Inventors:G. Lawrence ThatcherRobert J. Cottone
B29C 48/0022B29K 2067/046B29K 2105/0085B29K 2995/006C08L 2205/02B29C 45/0053A61L 31/148Y10T428/139A61L 27/58Y10T428/1352B29C 2793/0018A61L 27/18B29L 2031/7534A61L 31/06A61F 2210/0004A61K 9/10A61L 2300/606A61L 31/14B29C 2793/009C08L 2203/02C08G 63/91A61L 27/26A61F 2/82B29K 2995/0041A61L 2300/412A61L 31/18C08L 67/00A61F 2/915B29C 71/0063A61L 31/16
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Claims

Abstract

A crystallized bioabsorbable polymer scaffold comprises a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable. 
     
     
         2 . The bioabsorbable polymer scaffold of  claim 1 , wherein the scaffold is cold bendable at temperatures in a range of about 10° C. to about 30° C. 
     
     
         3 . The bioabsorbable polymer scaffold of  claim 1 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone). 
     
     
         4 . The bioabsorbable polymer scaffold of  claim 1 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone). 
     
     
         5 . The bioabsorbable polymer scaffold of  claim 1 , further comprising a poly (L-lactide) moiety or a poly (D-lactide) moiety or a poly L-lactide-co-PEG moiety or a poly D-lactide-co-PEG moiety. 
     
     
         6 . The bioabsorbable polymer scaffold of  claim 1 , wherein the composition includes increased hydrophilicity and free molecular volume allowing for uptake of water. 
     
     
         7 . The bioabsorbable polymer scaffold of  claim 1 , wherein the composition includes amorphous and semicrystalline polymer portions. 
     
     
         8 . The bioabsorbable polymer scaffold of  claim 7 , wherein a crystallinity and tensile strength of the composition is adjustable by elongation of the semicrystalline portion. 
     
     
         9 . The bioabsorbable polymer scaffold of  claim 1 , further comprising at least one radiopaque marker. 
     
     
         10 . A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold crystallizes in response to orthogonal strain. 
     
     
         11 . The bioabsorbable polymer scaffold of  claim 10 , wherein the scaffold includes struts that orient and crystallize in response to orthogonal strain upon deployment. 
     
     
         12 . The bioabsorbable polymer scaffold of  claim 10 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone). 
     
     
         13 . The bioabsorbable polymer scaffold of  claim 10 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone). 
     
     
         14 . The bioabsorbable polymer scaffold of  claim 10 , further comprising a poly (L-lactide) moiety or a poly (D-lactide) moiety or a poly L-lactide-co-PEG moiety or a poly D-lactide-co-PEG moiety. 
     
     
         15 . The bioabsorbable polymer scaffold of  claim 10 , wherein the composition includes increased hydrophilicity and free molecular volume allowing for uptake of water. 
     
     
         16 . The bioabsorbable polymer scaffold of  claim 10 , wherein the composition includes amorphous and semicrystalline polymer portions. 
     
     
         17 . The bioabsorbable polymer scaffold of  claim 10 , further comprising at least one radiopaque marker. 
     
     
         18 . A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone) wherein a contaminant monomeric residual fraction in the scaffold does not exceed about 0.5%. 
     
     
         19 . The bioabsorbable polymer scaffold of  claim 18 , wherein contaminant monomeric residual fraction in the scaffold does not exceed about 0.3%. 
     
     
         20 . The bioabsorbable polymer scaffold of  claim 18 , wherein contaminant monomeric residual fraction in the scaffold does not exceed about 0.2%. 
     
     
         21 . The bioabsorbable polymer scaffold of  claim 18 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone) or poly (D-lactide-co-ε-caprolactone). 
     
     
         22 . The bioabsorbable polymer scaffold of  claim 18 , wherein the polymer composition comprises poly (L-lactide-co-ε-caprolactone). 
     
     
         23 . The bioabsorbable polymer scaffold of  claim 18 , further comprising a poly (L-lactide) moiety or a poly (D-lactide) moiety or a poly L-lactide-co-PEG moiety or a poly D-lactide-co-PEG moiety. 
     
     
         24 . The bioabsorbable polymer scaffold of  claim 18 , wherein the composition includes increased hydrophilicity and free molecular volume allowing for uptake of water. 
     
     
         25 . The bioabsorbable polymer scaffold of  claim 18 , wherein the composition includes amorphous and semicrystalline polymer portions. 
     
     
         26 . The bioabsorbable polymer scaffold of  claim 25 , wherein a crystallinity and tensile strength of the composition is adjustable by elongation of the semicrystalline portion. 
     
     
         27 . The bioabsorbable polymer scaffold of  claim 18 , further comprising at least one radiopaque marker.

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