US2023141977A1PendingUtilityA1
Targeted gene modification using oligonucleotide-mediated gene repair
Est. expiryMar 15, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Peter R. BeethamGregory F.W. GocalChristian SchopkeNoel Joy SauerJames PearceRosa E. SegamiJerry Mozoruk
C12N 15/8213
69
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Claims
Abstract
The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.
Claims
exact text as granted — not AI-modified1 . A method for introducing a gene repair oligonucleobase (GRON)-mediated mutation into a target deoxyribonucleic acid (DNA) sequence in a cell, comprising: culturing the cell under conditions that increase one or more cellular DNA repair processes prior to, and/or coincident with, delivery of a GRON into the plant cell.
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