US2023144767A1PendingUtilityA1
Targeted nitroxide agents
Assignee: UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATIONPriority: Jul 17, 2008Filed: Jan 5, 2023Published: May 11, 2023
Est. expiryJul 17, 2028(~2 yrs left)· nominal 20-yr term from priority
C07D 209/46C07D 211/58C07C 237/16C07D 221/22C07D 471/08C07D 211/94A61K 31/454A61K 47/64C07D 401/12C07K 5/08C07D 279/06C07D 417/12A61P 17/18C07D 209/44A61P 39/06
83
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Claims
Abstract
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
Claims
exact text as granted — not AI-modified1 - 39 . (canceled)
40 . A compound of structure:
41 . A compound of structure:Join the waitlist — get patent alerts
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