Dental composition comprising chelator and base

Abstract

The present invention relates to non-toxic consumable compositions and formulations comprising chelator and base having synergistic effects on microbial metabolism and/or growth and/orpathogenic effectors and their use to promote and maintain health in mammals. The current invention also relates to non-toxic consumable compositions comprising more than one chelator and/or more than one base. The present invention further relates to methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used. The present invention relates to the synergistic compositions and methods of their use for maintaing health, promoting health and treating diseases.

1 . A composition comprising a chelator and a base, wherein the chelator and base provide microbial affecting activity. 
     
     
         2 . The composition of  claim 1 , wherein the chelator is selected from the group consisting of siderophores, natural chelators and synthetic chelators. 
     
     
         3 . The chelator of  claim 1 , wherein the chelator is cyclodextrin or cyclodextrin derivative, ferrichrome, citrate, EDTA, EGTA, pectin or modified pectin. 
     
     
         4 . The composition of  claim 1 , wherein more than one chelator is used. 
     
     
         5 . The composition of  claim 1 , wherein the concentration of chelator is between 0.0005% and 30% of the composition. 
     
     
         6 . The composition of  claim 1 , wherein the base is selected from the group consisting of natural bases, synthetic bases and agents having basic properties. 
     
     
         7 . The composition of  claim 6 , wherein the base is KOH, NaOH, pyridoxal-5-phosphate, pyridoxamine, pyridoxine. vitamin K, lysine, arginine, lysozyme, alpha-galactase, tris amine or sodium bicarbonate. 
     
     
         8 . The composition of  claim 1 , wherein more than one base is used. 
     
     
         9 . The composition of  claim 1 , wherein the concentration of base is between 0.0001% and 15% of the composition. 
     
     
         10 . The composition of  claim 1 , further comprising an enhancer. 
     
     
         11 . The composition of  claim 1 , wherein the enhancer is proline, phenylalanine, boric acid, ascorbic acid and extracts from citrus, berries, teas, peppermint, mint or cinnamon and the concentration is between 0.0001% and 10% of the composition. 
     
     
         12 . The composition of  claim 1 , wherein the composition is for oral care. 
     
     
         13 . The composition of  claim 1 , wherein the base comprises sodium bicarbonate and pyridoxal-5-phosphate and the chelator comprises alpha-cyclodextrin. 
     
     
         14 . The composition of  claim 1 , wherein the composition is formulated in a tablet, capsule, rapid melt tablet, thin strip, gum or mouthwash. 
     
     
         15 . The composition of  claim 1 , wherein the composition is formulated for administration at least once per day. 
     
     
         16 . The composition of  claim 1 , wherein the composition is used to promote oral health, treat or prevent cavities, periodontitis, halitosis and gingivitis. 
     
     
         17 . The composition of  claim 1 , wherein the composition is for use following consumption of a phosphoric acid or ascorbic acid containing beverage. 
     
     
         18 . The composition of  claim 1 , wherein the composition is for use following consumption of food. 
     
     
         19 . A method of promoting oral health in a mammal comprising:
 (i) identifying an individual at increased risk for developing or exhibiting signs of oral disease;   (ii) measuring pH, leukocyte esterase, nitrate, microbial marker levels, or plaque-staining dye retention in the mouth of the individual;   (iii) comparing said levels to healthy levels to determine if oral pathology is present; and   (iv) contacting an effective amount of a composition comprising a chelator and a base to the oral surface if evidence of oral pathology is present.   
     
     
         20 . The method of  claim 19 , wherein said method is repeated on a daily, a monthly, quarterly or annual basis. 
     
     
         21 . The method of  claim 19 , wherein the composition comprises EDTA or alpha-cyclodextrin and sodium bicarbonate or pyridoxal-5-phosphate. 
     
     
         22 . The method of  claim 21 , wherein the EDTA and alpha-cyclodextrin comprises between 0.0001% and 30% of the composition. 
     
     
         23 . The method of  claim 21 , wherein the effective amount of sodium bicarbonate and pyridoxa1-5-phosphate is between 0.0001% and 15% of the composition. 
     
     
         24 . The method of  claim 19 , wherein oral pathology is indicated by the individual having an oral pH below 6.2. 
     
     
         25 . The method of  claim 19 , wherein the individual is determined to have oral pathology based on the presence of one or more of halitosis, tooth plaque, tooth decay, or a cavity. 
     
     
         26 . The method of  claim 19 , wherein the individual is determined to have oral pathology based on the presence of  Streptococcus mutans .