Allergic Rhinitis Drug Delivery Implant

Abstract

In an example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.

1 . A method comprising:
 delivering a bioresorbable implant through a cannula under direct visualization to a nasal passage, wherein the bioresorbable implant comprises a plurality of bioresorbable textile fibers comprising:
 one or more biodegradable polymers, and 
 a pharmaceutical composition coupled to the one or more biodegradable polymers; and 
   after delivering the bioresorbable implant the nasal passage, releasing the pharmaceutical composition from the pharmaceutical composition,   wherein the one or more biodegradable polymers are configured to control a release rate of the pharmaceutical composition over time.   
     
     
         2 . The method of  claim 1 , wherein the one or more biodegradable polymers comprise a plurality of different biodegradable polymers with different degradation rates such that releasing the pharmaceutical composition comprises releasing the pharmaceutical composition at a plurality of release rates, which are different from each other. 
     
     
         3 . The method of  claim 1 , wherein the bioresorbable implant comprises a plurality of segments, and
 wherein each segment comprises a different biodegradable polymer such that releasing the pharmaceutical composition comprises releasing the pharmaceutical composition at a plurality of release rates that are different from each other.   
     
     
         4 . (canceled) 
     
     
         5 . The method of  claim 1 , wherein the bioresorbable implant comprises a tip having a pointed shape, and
 wherein delivering the bioresorbable implant to the nasal passage comprises piercing and penetrating a soft tissue in the nasal passage using the tip of the bioresorbable implant.   
     
     
         6 . The method of  claim 5 , wherein delivering the bioresorbable implant comprises delivering the bioresorbable implant using a delivery device attached to a distal end of an endoscope. 
     
     
         7 . The method of  claim 1 , wherein the pharmaceutical composition comprises at least one of:
 one or more drugs, or   one or more therapeutic agents.   
     
     
         8 . A bioresorbable implant for use in a nasal region, comprising:
 a polymeric bioresorbable substrate in the form of a rod or a tube; and   a bioresorbable polymeric coating comprising a pharmaceutical composition and coupled to the polymeric bioresorbable substrate,   wherein a release rate of the pharmaceutical composition is related to a degradation rate of the bioresorbable polymeric coating.   
     
     
         9 .- 10 . (canceled) 
     
     
         11 . The bioresorbable implant of  claim 8 , wherein the polymeric bioresorbable substrate comprises the pharmaceutical composition. 
     
     
         12 . The bioresorbable implant of  claim 8 , wherein the bioresorbable implant comprises a plurality of segments. 
     
     
         13 . (canceled) 
     
     
         14 . The bioresorbable implant of  claim 8 , wherein the bioresorbable implant comprises a tip having a pointed shape. 
     
     
         15 . The bioresorbable implant of  claim 8 , wherein an end of the bioresorbable implant is flared. 
     
     
         16 . A system, comprising:
 a bioresorbable implant comprising:
 a polymeric bioresorbable substrate in the form of a rod or a tube; and 
 a bioresorbable polymeric coating comprising a pharmaceutical composition and coupled to the polymeric bioresorbable substrate, 
 wherein a release rate of the pharmaceutical composition is related to a degradation rate of the bioresorbable polymeric coating; and 
   a delivery device configured to deliver the bioresorbable implant to a nasal region.   
     
     
         17 . The system of  claim 16 , wherein the delivery device comprises a needle having a lumen, and
 wherein the bioresorbable implant is deliverable to the nasal region via the lumen of the needle.   
     
     
         18 . The system of  claim 16 , wherein the delivery device comprises an elongated shaft having a distal end releasably coupled to a proximal end of the bioresorbable implant. 
     
     
         19 . The system of  claim 18 , wherein the bioresorbable implant comprises a tip having a pointed shape configured to pierce and penetrate a soft tissue in the nasal region. 
     
     
         20 . (canceled) 
     
     
         21 . The method of  claim 1 , wherein the bioresorbable implant comprises one or more layers of the pharmaceutical composition, one more layers of parylene, and one or more layers of a polymeric bioresorbable substrate arranged in stack. 
     
     
         22 . The bioresorbable implant of  claim 8 , wherein one or more bioresorbable polymers of the polymeric bioresorbable substrate are different from one or more bioresorbable polymers of the bioresorbable polymeric coating. 
     
     
         23 . The bioresorbable implant of  claim 8 , wherein the polymeric bioresorbable substrate comprises the pharmaceutical composition. 
     
     
         24 . The bioresorbable implant of  claim 23 , wherein the pharmaceutical composition of the polymeric bioresorbable substrate is different from the pharmaceutical composition of the bioresorbable polymeric coating. 
     
     
         25 . The bioresorbable implant of  claim 23 , wherein the pharmaceutical composition of the bioresorbable polymeric coating is drug-free, and wherein the bioresorbable polymeric coating is configured to inhibit a burst release of the pharmaceutical composition in the polymeric bioresorbable substrate. 
     
     
         26 . The bioresorbable implant of  claim 22 , wherein the bioresorbable polymeric coating and the polymeric bioresorbable substrate form a plurality of layers made of different respective polymeric materials. 
     
     
         27 . The bioresorbable implant of  claim 8 , further comprising:
 a release-control layer enclosing the bioresorbable polymeric coating, which encloses the polymeric bioresorbable substrate.