Drug delivery systems comprising an intraocular pressure lowering agent, a neurotrophic agent, a c-type natriuretic peptide, a natriuretic peptide receptor-b, an apoptosis signaling fragment inhibitor or a fas-ligand inhibitor for treating glaucoma or ocular hypertension

Abstract

This disclosure relates to a drug delivery system comprising an intraocular pressure lowering agent, a neurotrophic agent, such as a CNTF compound, a C-type Natriuretic Peptide (CNP) compound, a Tie-2 agonist, a Natriuretic Peptide Receptor-B (NPR-B) compound, or an apoptosis signaling fragment inhibitor (FAS) or FAS-ligand (FASL) inhibitor, including any combination of these compounds and a sustained delivery component. Methods of treating a glaucoma or related conditions, medicaments, kits, uses and methods of manufacturing are also described.

1 . A drug delivery system comprising: 1) a prostaglandin, a CNTF compound, a TNF-α/TNFR inhibitor, a FAS or FASL inhibitor, or a combination thereof, and 2) a sustained delivery component. 
     
     
         2 . The drug delivery system of  claim 1 , comprising: 1) the prostaglandin, 2) the CNTF compound, the FAS or FASL inhibitor, or the combination thereof, and 3) the sustained delivery component. 
     
     
         3 . The drug delivery system of  claim 2 , wherein the CNTF compound is a peptide comprising the amino acid sequence DGGL (SEQ ID NO: 20) or a salt thereof. 
     
     
         4 . The drug delivery system of  claim 2 , wherein the prostaglandin is bimatoprost acid or a salt thereof. 
     
     
         5 . The drug delivery system of  claim 4 , comprising the prostaglandin and the CNTF compound, wherein the CNTF compound is Peptide 6 or a salt thereof. 
     
     
         6 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is bicyclol. 
     
     
         7 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is a peptide comprising the amino acid sequence YLGA (SEQ ID NO: 5) or a salt thereof. 
     
     
         8 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is MET4. 
     
     
         9 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is MET5. 
     
     
         10 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is MET6. 
     
     
         11 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is MET7. 
     
     
         12 . The drug delivery system of  claim 2 , wherein the FAS or FASL inhibitor is MET8. 
     
     
         13 . The drug delivery system of  claim 2 , wherein the prostaglandin is not covalently bonded or covalently linked to the CNTF compound, the FAS or FASL inhibitor, or the combination thereof. 
     
     
         14 . The drug delivery system of  claim 2 , wherein the prostaglandin is covalently bonded or covalently linked to the CNTF compound, the FAS or FASL inhibitor, or the combination thereof. 
     
     
         15 . The drug delivery system of  claim 1 , wherein the prostaglandin, the CNTF compound, the FAS or FASL inhibitor, or the combination thereof is covalently bonded or linked to the sustained delivery component. 
     
     
         16 . A method of treating a glaucoma or ocular hypertension comprising administering a drug delivery system of  claim 1  to an eye of a mammal in need thereof, wherein administering the drug delivery system to the eye of the mammal results in a reduction in the intraocular pressure of the eye of the mammal. 
     
     
         17 . (canceled) 
     
     
         18 . The method of  claim 16 , wherein the CNTF compound is Peptide 6 or Peptide 21. 
     
     
         19 . The method of  claim 16 , wherein the prostaglandin is bimatoprost acid or a salt thereof. 
     
     
         20 . The method of  claim 16 , wherein the FAS or FASL inhibitor is MET4-8. 
     
     
         21 . The method of  claim 16 , wherein the CNTF compound is a peptide comprising the amino acid sequence DGGL (SEQ ID NO: 20) or a salt thereof. 
     
     
         22 . (canceled)