Compositions and methods for joint health

Abstract

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

1 - 85 : (canceled) 
     
     
         86 . A composition for joint health, comprising:
 a mixture of a  Morus alba  extract enriched for one or more prenylated flavonoids and a  Curcuma longa  extract enriched for one or more curcuminoids.   
     
     
         87 . The composition according to  claim 86 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient to form a pharmaceutical or nutraceutical formulation, and wherein the pharmaceutical or nutraceutical formulation comprises from about 0.5 weight percent (wt %) to about 90 wt % of active ingredients of the extract mixture. 
     
     
         88 . A method for supporting a normal and comfortable range of motion and/or flexibility in a mammal, comprising administering an effective amount of a composition according  claim 86 . 
     
     
         89 . A method for reducing the action of harmful enzymes that break down protective joint tissues in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         90 . A method for improving joint movement and/or joint function in a mammal comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         91 . A method for alleviating joint pain and/or joint stiffness in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         92 . A method for managing and maintaining physical mobility of a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         93 . A method for improving range of motion and/or flexibility of a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         94 . A method for improving joint physical function in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         95 . A method for relieving joint discomfort in a mammal caused by exercise, work, overexertion or any combination thereof, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         96 . A method for promoting healthy joints in a mammal by protecting cartilage integrity, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         97 . A method for treating, preventing, or managing cartilage degradation in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         98 . A method for promoting joint health or comfort by maintaining synovial fluid for joint lubrication in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         99 . A method for promoting joint comfort and a wide range of motion in a mammal after exercise, work, overexertion or any combination thereof, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         100 . A method for treating arthritis in a mammal, comprising administering an effective amount of a composition according to  claim 86 . 
     
     
         101 . The method according to  claim 100 , wherein the arthritis is osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, Still's disease, psoriatic arthritis, reactive arthritis, septic arthritis, Reiter's syndrome, Behcet's syndrome, or Felty's syndrome.