Dodecafluoropentane emulsion as a stroke and ischemia therapy

Abstract

The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.

1 - 21 . (canceled) 
     
     
         22 . A method for improving tissue oxygenation and/or neuroprotection in a subject at risk for ischemic tissue damage, the method comprising injecting intravenously into said subject as a bolus, at a time ranging from immediately after the start of the ischemic event to a time ranging from 1 hour after the onset of symptoms to 24 hours after the onset of symptoms, an effective amount of a perfluorocarbon emulsion comprising about 1% to about 5% w/v of dodecafluoropentane at a dosage of about 0.01 ml/kg to about 1 ml/kg of the subject prior to a medical procedure that results in the subject being at high risk of ischemic tissue damage. 
     
     
         23 . The method of  claim 22 , wherein the medical procedure is selected from the group consisting of cardiac surgery, open surgery, orthopedic surgery, and skeletal surgery, angioplasty, stenting, device implantation, and ablations. 
     
     
         24 . The method of  claim 22 , wherein the subject is administered the perfluorocarbon emulsion in combination with a second agent selected from the group consisting of an anticoagulant, thrombolytic agent, which may include tPA, and oxygen inhalation. 
     
     
         25 . The method of  claim 22 , wherein the infarct volume is reduced without incidence of brain hemorrhage. 
     
     
         26 . The method of  claim 22 , wherein the ischemic tissue damage is neural ischemic tissue damage.