US2023192868A1PendingUtilityA1
Anti-igf-i receptor antibody
Est. expiryMay 30, 2037(~10.9 yrs left)· nominal 20-yr term from priority
A61K 45/06A01K 2267/01A61K 39/3955A01K 2207/15A61K 2039/545A61P 21/00A01K 2217/052A61P 3/10C12N 15/8509C07K 16/2863A61K 9/0029C12N 5/0658A01K 67/0278A61P 21/04C07K 2317/33A61P 27/02C07K 2317/73C07K 2317/92A61P 11/00C07K 2317/622A61P 35/02A61P 25/00A61P 13/12A61P 13/10A61K 2039/505A61P 3/04C07K 2317/75A61P 1/18A61K 35/76C07K 2317/74A01K 67/027A61P 15/00C07K 2317/34A61P 13/08A61K 35/34A61P 37/06C07K 2317/31A61P 19/10C12N 15/63C07K 2317/565C07K 2317/24C07K 16/28C07K 2317/20A61P 1/12C12N 2501/998A61P 17/02A61P 3/00A61P 17/06C12N 2015/8518A61P 21/02A61P 27/16A61K 39/395A61P 1/16A61K 35/12A61P 35/00C07K 2317/14A61P 9/00C07K 2317/567A61K 48/00C12N 5/10A61P 9/10C12N 2506/1323A61K 2039/55C07K 2317/55C07K 2317/626A61P 19/08A61K 45/00A61P 9/14A61P 1/04G01N 33/5088
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Claims
Abstract
The present invention provides an anti-IGF-I receptor antibody that binds specifically to an IGF-I receptor of a vertebrate and has the proliferation-inducing activity of a vertebrate-derived cell, or a fragment thereof, or derivatives of these.
Claims
exact text as granted — not AI-modified1 . An animal with genetic modification for evaluating the activity of an anti-IGF-I receptor antibody or its fragment or a derivative thereof on vertebrate, wherein the animal's innate IGF-I receptor gene which has been mutated in a CR domain thereof and the mutated CR domain encodes an amino acid sequence represented by ProSerGlyPhelleArgAsnGlySerGlnSerMet.
2 . An animal with genetic modification for evaluating the activity of an anti-IGF-I receptor antibody or its fragment or a derivative thereof on vertebrate, wherein the animal's innate IGF-I receptor gene which has been mutated in a CR domain thereof, and amino acid residue(s) X 1 and/or X 2 of a sequence represented by ProSerGlyPheIleArgAsnX 1 × 2 GlnSerMet in the mutated CR domain differs from that of the animal's innate IGF-I receptor gene.Join the waitlist — get patent alerts
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