Flexible substrates for nucleic acid synthesis

Abstract

Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage. Further described herein are highly efficient methods for long term data storage with 100% accuracy in the retention of information. Additionally, devices described herein for de novo synthesis of oligonucleic acids encoding information related to the original source information may have a flexible material for oligonucleic acids extension.

1 .- 45 . (canceled) 
     
     
         46 . A nucleic acid library comprising:
 a plurality of oligonucleic acids comprising DNA sequence data, wherein the DNA sequence data is representative of one or more items of information, and   wherein the one or more items of information comprise at least 20 megabytes.   
     
     
         47 . The nucleic acid library of  claim 46 , wherein the nucleic acid library comprises at least 1 million non-identical nucleic acids. 
     
     
         48 . The nucleic acid library of  claim 46 , wherein the nucleic acid library comprises at least 10 million non-identical nucleic acids. 
     
     
         49 . The nucleic acid library of  claim 46 , wherein at least one of the items of information comprises at least 20 megabytes of information. 
     
     
         50 . The nucleic acid library of  claim 46 , wherein the nucleic acid library comprises at least 200 megabytes of information. 
     
     
         51 . The nucleic acid library of  claim 46 , wherein the nucleic acid library comprises a density of at least 20 megabytes per nucleic acid. 
     
     
         52 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises binary data. 
     
     
         53 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises a plurality of strings. 
     
     
         54 . The nucleic acid library of  claim 53 , wherein the oligonucleic acids are representative of the plurality of strings. 
     
     
         55 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises one or more of text, audio and visual information. 
     
     
         56 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises one or more of books, periodicals, electronic databases, medical records, letters, forms, voice recordings, animal recordings, biological profiles, broadcasts, films, short videos, emails, bookkeeping phone logs, internet activity logs, drawings, paintings, prints, photographs, pixelated graphics, and software code. 
     
     
         57 . The nucleic acid library of  claim 46 , wherein the one or more items of information is present in more than one language. 
     
     
         58 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises a biological profile. 
     
     
         59 . The nucleic acid library of  claim 46 , wherein the one or more items of information comprises one or more of gene libraries, genomes, gene expression data, and protein activity data. 
     
     
         60 . The nucleic acid library of  claim 46 , wherein the format of the one or more items of information comprises one or more of .txt, .PDF, .doc, .docx, .ppt, .pptx, .xls, .xlsx, .rtf, .jpg, .gif, .psd, .bmp, .tiff, .png, and .mpeg. 
     
     
         61 . The nucleic acid library of  claim 46 , wherein the one or more items of information is organized into one or more files. 
     
     
         62 . The nucleic acid library of  claim 61 , wherein the one or more files comprises at least 1024 bytes, 1024 KB, 1024 MB, or 1024 GB. 
     
     
         63 . The nucleic acid library of  claim 46 , wherein the nucleic acid library is stored in-vitro. 
     
     
         64 . The nucleic acid library of  claim 46 , wherein each of the nucleic acids is no more than 200 bases in length.