Fast Disintegrating Cannabinoid Tablets

Abstract

The present invention relates in a first aspect to a fast disintegrating cannabinoid tablet, the tablet comprising a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of at least 20% by weight of the tablet, a cannabinoid composition comprising one or more cannabinoids, and a disintegrant composition comprising one or more disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva. In a second aspect, the invention relates to a modular tablet, wherein the tablet comprises a further tablet module that is different in composition.

1 . A single-layered compressed cannabinoid tablet, the tablet comprising a tablet formulation including:
 a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of 50 to 90% by weight of the tablet,   a cannabinoid composition comprising one or more cannabinoids, and   a disintegrant composition comprising one or more disintegrants in an amount of 0.5 to 25% by weight of the tablet operable to disintegrate the tablet within a period of 2 minutes or less than 2 minutes in contact with oral saliva,   wherein at least a part of the one or more cannabinoids is reversibly associated with at least a part of the one or more sugar alcohol particles by means of adsorption to said one or more sugar alcohol particles in a premixture prior to being applied in the tablet formulation.   
     
     
         2 . The tablet according to  claim 1 , wherein the one or more disintegrants is present in an amount of 2 to 15% by weight of the tablet. 
     
     
         3 . The tablet according to  claim 1 , wherein the one or more disintegrants is swellable in contact with oral saliva. 
     
     
         4 . The tablet according to  claim 1 , wherein the one or more disintegrants comprises starch. 
     
     
         5 . The tablet according to  claim 1 , wherein the one or more disintegrants comprises microcrystalline cellulose. 
     
     
         6 . The tablet according to  claim 1 , wherein the one or more disintegrants comprises a super disintegrant. 
     
     
         7 . The tablet according to  claim 1 , wherein the one or more disintegrants comprises a super disintegrant selected from the group consisting of sodium croscarmellose, crospovidone, sodium starch glycolate, and combinations thereof. 
     
     
         8 . The tablet according to  claim 1 , wherein the one or more disintegrants comprises cross-linked polyvinylpyrrolidone. 
     
     
         9 . The tablet according to  claim 1 , wherein the one or more sugar alcohol particles is selected from the group consisting of xylitol, lactitol, sorbitol, maltitol, erythritol, isomalt, mannitol, and combinations thereof. 
     
     
         10 . The tablet according to  claim 1 , wherein the premixture is present in a ratio of 1:10 to 1:4 by weight of the one or more sugar alcohol particles. 
     
     
         11 . The tablet according to  claim 1 , wherein the weight ratio of the one or more cannabinoids relative to the one or more sugar alcohol particles is from 1:30 to 1:1. 
     
     
         12 . The tablet according to  claim 1 , further comprising a binder, such as a dry or wet binder. 
     
     
         13 . The tablet according to  claim 1 , wherein the tablet does not include added liquid solvent for the one or more cannabinoids. 
     
     
         14 . The tablet according to  claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), and combinations thereof. 
     
     
         15 . The tablet according to  claim 1 , wherein the one or more cannabinoids is selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), and combinations thereof. 
     
     
         16 . The tablet according to  claim 1 , wherein the one or more cannabinoids comprises at least one phytocannabinoid that forms part of an extract. 
     
     
         17 . The tablet according to  claim 1 , wherein the one or more cannabinoids comprises at least one isolated cannabinoid. 
     
     
         18 . The tablet according to  claim 1 , wherein the tablet comprises a self-emulsifying agent. 
     
     
         19 . The tablet according to  claim 1 , wherein the tablet comprises a lipid carrier for the one or more cannabinoids. 
     
     
         20 . The tablet according to  claim 1 , wherein the one or more cannabinoids is not adsorbed to silica. 
     
     
         21 . A compressed cannabinoid tablet, the tablet comprising a tablet formulation including:
 a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of 30 to 90% by weight of the tablet,   a cannabinoid composition comprising one or more cannabinoids, and   a disintegrant composition comprising one or more disintegrants in an amount of 2 to 15% by weight of the tablet operable to disintegrate said tablet within a period of 2 minutes or less than 2 minutes in contact with oral saliva,   wherein at least a part of the one or more cannabinoids is reversibly associated with at least a part of the one or more sugar alcohol particles by means of adsorption to said one or more sugar alcohol particles in a premixture prior to being applied in the tablet formulation.   
     
     
         22 . A cannabinoid tablet, the tablet comprising a tablet formulation including:
 a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of 50 to 90% by weight of the tablet,   a cannabinoid composition comprising one or more cannabinoids, and   a disintegrant composition comprising one or more disintegrants in an amount of 2 to 15% by weight of the tablet operable to disintegrate said tablet within a period of 2 minutes or less than 2 minutes in contact with oral saliva,   wherein at least a part of the one or more cannabinoids is adsorbed to at least a part of the one or more sugar alcohol particles in a premixture prior to being applied in the tablet formulation.   
     
     
         23 . The tablet according to  claim 22 , wherein the premixture is present in a ratio of 1:10 to 1:4 by weight of the one or more sugar alcohol particles. 
     
     
         24 . The tablet according to  claim 22 , wherein the premixture is present in a ratio of 1:20 to 1:2 by weight of the one or more sugar alcohol particles.