Dexamethasone prodrug compositions and uses thereof

Abstract

The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

1 . A compound described by the formula (A-IV): 
       
         
           
           
               
               
           
         
       
        or a pharmaceutically acceptable salt thereof, wherein
 L is —C(O)O—(R A )—OC(O)—; 
 R A  is selected from C 1-20  alkylene, a linear or branched heteroalkylene of 1 to 20 atoms, a linear or branched C 2-20  alkenylene, a linear or branched C 2-20  alkynylene, a C 5-10  arylene, a cyclic system of 3 to 10 atoms, or O—(R A )—O is a radical of a polyol and comprises at least one free hydroxyl group or O—(R A )—O is selected from:
 —O(CH 2 CH 2 O)nCH 2 CH 2 O—, 
 —O(CH 2 CH 2 CH 2 CH 2 O)mCH 2 CH 2 CH 2 CH 2 O—, or 
 —O(CH 2 CH(CH 3 )O)pCH 2 CH(CH 3 )O—; and 
 n, m, and p are integers from 1 to 10.