Composition of lactic bacteria for use in the treatment of infections due to propionibacterium acnes and in particular for acne

Abstract

The present invention relates to selected strains of lactic bacteria for use in the treatment of infections caused by pathogenic bacteria belonging to the species Propionibacterium acnes , in particular for use in the preventive and/or curative treatment of dermatitis in general, seborrheic dermatitis, rosacea, eczema and acne. In addition, the present invention relates to a composition which comprises a mixture comprising or, alternatively, consisting of selected strains of lactic bacteria for use in the treatment of infections caused by pathogenic bacteria belonging to the species Propionibacterium acnes , in particular for use in the preventive and/or curative treatment of dermatitis in general, seborrheic dermatitis, rosacea, eczema and acne. The composition comprising said mixture of selected strains of lactic bacteria is formulated in a pharmaceutical form for oral use (novel food, supplement product or medical device or pharmaceutical composition) in the form of powder, dispersible powder, granulate, packets or stick, solution, spray solution, syrup, tablet, capsule, pill or lozenge; or for topical use (composition for medical device or pharmaceutical composition) in the form of cream, ointment, pomade, gel, hydrogel, dispersion, emulsion or spray to be used as such for skin applications, or for transdermal use even in the form of a band aid.

1 - 14 . (canceled) 
     
     
         15 . A composition comprising cells of the strain  Lactobacillus salivarius  LS03 (ID 1382) (deposited at the DSMZ as DSM 22776). 
     
     
         16 . The composition of  claim 15 , wherein the composition is formulated as a cream, ointment or gel for topical use. 
     
     
         17 . The composition of  claim 15 , wherein the composition is a transdermal patch. 
     
     
         18 . The composition of  claim 15 , wherein the composition comprises live bacterial cells. 
     
     
         19 . The composition of  claim 15 , wherein the composition comprises dead bacterial cells. 
     
     
         20 . The composition of  claim 15 , further comprising:
 cells of the strain  Lactobacillus delbrueckii  ssp.  delbrueckii  LDD01 (deposited at the DSMZ as DSM 22106),   cells of the strain  Lactobacillus reuteri  LRE04 (deposited at the DSMZ as DSM 23880), and/or   cells of the strain  Bifidobacterium pseudolongum  ssp.  globosum  BPS01 (deposited at the DSMZ as DSM 26456).   
     
     
         21 . The composition of  claim 20 , wherein the strain of  Lactobacillus salivarius  LS03 and the strain of  Lactobacillus delbrueckii  ssp.  delbrueckii  LDD01 are, respectively, in a weight ratio of about 1:1, or 2:1, or 3:1, or 4:1, or 5:1, or 1:2. 
     
     
         22 . The composition of  claim 20 , wherein the strain of  Lactobacillus salivarius  LS03 and the strain of  Lactobacillus reuteri  LRE04 are, respectively, in a weight ratio of about 1:1, or 2:1, or 3:1, or 4:1, or 5:1, or 1:2. 
     
     
         23 . The composition of  claim 15 , wherein said composition further comprises ammonium lactate.