Novel fine particle coating (drug-containing hollow particle and method for manufacturing same)

Abstract

Provided is a manufacturing method of particles coated with coatable microparticles. The method is a manufacturing method of particles coated with coatable microparticles, comprising the step of adding the coatable microparticles to an inner core comprising a component of interest and a macromolecule, and, while rolling the mixture, coating the mixture while spraying a solvent that can dissolve the macromolecule, wherein the particles coated with the coatable microparticles are coated, component of interest-containing hollow particles.

1 . A composition, comprising hollow particles coated with coatable microparticles,
 wherein the hollow particles comprise   (i) an inner core that is a nuclear particle having a shell and a hollow section and including a component of interest and a macromolecule, and   (ii) a coating layer comprising a plurality of coatable microparticles which accumulate on the outer portion of the inner core, and   the composition has a property of imparting a sustained release, enteric, stomach soluble, bitterness masking, or photostable function to the nuclear particle.   
     
     
         2 . The composition of  claim 1 , wherein the sustained release, enteric, stomach soluble, bitterness masking, or photostable function is imparted to the nuclear particle by the coatable microparticles. 
     
     
         3 . The composition of  claim 1 , wherein the coatable microparticles provide a photostability function to the nuclear particle. 
     
     
         4 . The composition of  claim 2 , wherein the composition has a property of enhancing a property of a macromolecule included in the shell of the nuclear particle. 
     
     
         5 . The composition of  claim 1 , wherein the composition has at least one property selected from the group consisting of enhancing a sustained release, enteric, stomach soluble, and bitterness masking property of the nuclear particle. 
     
     
         6 . The composition of  claim 1 , wherein the coatable microparticles provide a sustained release property to the nuclear particle. 
     
     
         7 . The composition of  claim 1 , wherein the coatable microparticles have a D90 value of 100 μm or less. 
     
     
         8 . The composition of  claim 1 , wherein the coatable microparticles have a mean particle size of 25 μm or less. 
     
     
         9 . The composition of  claim 1 , wherein the coatable microparticles have a D100 value of 150 μm or less. 
     
     
         10 . The composition of  claim 1 , wherein the coatable microparticles have a particle size such that all of the coatable microparticles pass through a 100 mesh sieve. 
     
     
         11 . The composition of  claim 1 , wherein the coatable microparticles comprise at least one selected from the group consisting of celluloses, stearic acid, stearate, talc, oil and fat, metal oxide, stearyl fumarate salt, and alginic acid. 
     
     
         12 . The composition of  claim 1 , wherein the coatable microparticles comprise at least one selected from the group consisting of talc, Red Ferric Oxide, Yellow Ferric Oxide, titanium oxide, sodium stearyl fumarate, and sodium stearate. 
     
     
         13 . The composition of  claim 1 , wherein the shell comprises the component of interest and the macromolecule. 
     
     
         14 . The composition of  claim 1 , wherein the component of interest is a drug, a cosmetic, an agricultural chemical, a supplement, or a food product. 
     
     
         15 . Particles coated with coatable microparticles, comprising:
 an inner core comprising a shell and a hollow section; and   a coating layer comprising a plurality of coatable microparticles which accumulate on the outer portion of the inner core,   wherein the inner core and the coating layer comprise a same macromolecule, and   the coatable microparticles enhance a property of the macromolecule of the inner core.   
     
     
         16 . The particles of  claim 15 , wherein the coatable microparticles have a D90 value of 100 μm or less. 
     
     
         17 . The particles of  claim 15 , wherein the coatable microparticles have a mean particle size of 25 μm or less. 
     
     
         18 . The particles of  claim 15 , wherein the coatable microparticles have a D100 value of 150 μm or less. 
     
     
         19 . The particles of  claim 15 , wherein the coatable microparticles have a particle size such that all of the coatable microparticles pass through a 100 mesh sieve. 
     
     
         20 . The particles of  claim 15 , wherein the coatable microparticles comprise at least one selected from the group consisting of celluloses, stearic acid, stearate, talc, oil and fat, metal oxide, stearyl fumarate salt, and alginic acid. 
     
     
         21 . The particles of  claim 15 , wherein the coatable microparticles comprise at least one selected from the group consisting of talc, Red Ferric Oxide, Yellow Ferric Oxide, titanium oxide, sodium stearyl fumarate, and sodium stearate.